无镇静胃镜检查后不良反应的危险因素分析

doi:10.3969/j.issn.1006-7795.2025.04.014

首都医科大学学报 ›› 2025, Vol. 46 ›› Issue (4): 676-681.doi: 10.3969/j.issn.1006-7795.2025.04.014

无镇静胃镜检查后不良反应的危险因素分析

杨舒悦，刘思凡，冀旭，赵梦冉，张政，李鹏^*

首都医科大学附属北京友谊医院消化科消化健康全国重点实验室国家消化系统疾病临床医学研究中心胃肠早癌药械研发北京市重点实验室，北京 100050

收稿日期:2025-04-01 出版日期:2025-08-21 发布日期:2025-09-01
通讯作者: 李鹏 E-mail:lipeng@ccmu.edu.cn
基金资助:
北京市医院管理中心“登峰”人才计划项目（DFL20220101）；研究型病房卓越临床研究计划-子课题8项目（BRWEP2024W162020108）。

Analysis on risk factors of adverse events after non-sedated esophagogastroduo-denoscopy

Yang Shuyue, Liu Sifan, Ji Xu, Zhao Mengran, Zhang Zheng, Li Peng^*

Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University；State Key Laboratory of Digestive Health； National Clinical Research Center for Digestive Diseases，Beijing Key Laboratory of Early Gastrointestinal Cancer Medicine and Medical Devices, Beijing 100050，China

Received:2025-04-01 Online:2025-08-21 Published:2025-09-01
Supported by:
This study was supported by Beijing Hospitals Authority “Dengfeng” Talent Training Plan (DFL20220101)；The Outstanding Clinical Research Program of Research Ward-Subproject 8 （BRWEP2024W162020108）.

摘要/Abstract

摘要： 目的探究无镇静胃镜检查后出现不良反应的可能危险因素。方法回顾性收集2018年5月至2019年6月2 384例行无镇静胃肠镜检查患者的临床资料，包括患者的一般情况、既往史、检查后的不良反应发生情况，分析胃镜检查后出现不良反应的危险因素。结果 2 384例行无镇静胃镜检查的患者中，1 375例(57.67%)出现恶心症状，305例(12.79%)出现呕吐症状，138例(5.79%)出现咽痛症状。多因素回归分析显示，患者年龄≥65周岁(OR=0.683, 95%CI:0.506~0.921)是无镇静胃镜检查后出现恶心不良反应的保护因素，高血压病史(OR=1.361,95%CI: 1.026~1.806)、超重(OR=1.399,95%CI:1.154~1.695)、肥胖(OR=2.594,95% CI:1.760~3.823)、检查时长超过15 min(OR=3.107, 95%CI:2.296~4.206)为无镇静胃镜检查后出现恶心不良反应的独立危险因素。患者高龄(OR=0.393,95%CI: 0.221~0.699)、应用进口内镜(OR=0.697,95%CI:0.546~0.890)为无镇静胃镜检查后出现呕吐不良反应的保护因素，检查时长>15 min(OR=1.641, 95%CI:1.008~2.669)是无镇静胃镜检查后出现呕吐不良反应的危险因素。检查后不良反应发生率在无镇静胃镜检查成功与否间差异无统计学意义(P<0.05)。结论高血压、超重、肥胖的患者行无镇静胃镜检查后出现恶心不良反应的可能性较高，高龄患者与应用进口胃镜检查的患者发生呕吐的可能性较小。同时检查时长>15 min是无镇静胃镜检查后出现恶心、呕吐等不良反应的危险因素。无镇静胃镜检查后不良反应发生与否与检查成功率之间并无关系。

关键词: 胃镜检查, 无镇静, 危险因素, 不良反应, 国产内镜, Logistic回归分析

Abstract: Objective To investigate the risk factor for adverse events(AEs) after non-sedated esophagogastroduodenoscopy (EGD). Methods The data on clinical manifestations, adverse events after non-sedated EGD and common risk factors were collected and retrospectively analyzed with statistical methods in patients who underwent non-sedated EGD from May 2018 to June 2019. These patients were divided into AEs group and non-AEs group. Results Of 2 384 patients, 57.67%(1 375/2 384) presented with nausea, 12.79%(305/2 384) vomiting, and 5.79%(138/2 384) presented with pharyngalgia. Multivariate Logistic regression analysis was performed. Advanced age(≥65 years old) (OR=0.683, 95%CI:0.506-0.921) was protective factors for nausea after non-sedated EGD. Hypertension (OR=1.361,95%CI:1.026-1.806), overweight (OR=1.399,95%CI:1.154-1.695), obesity(OR=2.594,95% CI:1.760-3.823) and inspection duration ＞15 min (OR=3.107, 95%CI:2.296-4.206) were independent risk factors for nausea after non-sedated EGD. Advanced age (OR=0.393, 95%CI: 0.221-0.699) and imported equipment (OR=0.697, 95%CI:0.546-0.890) were protective factors for vomiting after non-sedated EGD. Moreover, inspection duration ＞15 min (OR=1.641, 95%CI:1.008-2.699) was independent risk factors for vomiting after non-sedated EGD. There was no difference in success rate of non-sedated EGD between two groups(P<0.05). Conclusion Hypertension, overweight and obesity were independent risk factors for nausea after non-sedated EGD. The advanced age and imported equipment were protective factors for vomiting after non-sedated EGD. In addition, inspection duration over 15 min is a risk factor for AEs such as nausea and vomiting after nonsedative EGD. Whether AEs occurred or not is non-related to success rate of non-sedated EGD.

Key words: esophagogastroduodenoscopy, non-sedated, risk factors, adverse events, domestic endoscopy, Logistic regression analysis

中图分类号:

R573

杨舒悦, 刘思凡, 冀旭, 赵梦冉, 张政, 李鹏. 无镇静胃镜检查后不良反应的危险因素分析[J]. 首都医科大学学报, 2025, 46(4): 676-681.

Yang Shuyue, Liu Sifan, Ji Xu, Zhao Mengran, Zhang Zheng, Li Peng. Analysis on risk factors of adverse events after non-sedated esophagogastroduo-denoscopy[J]. Journal of Capital Medical University, 2025, 46(4): 676-681.

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无镇静胃镜检查后不良反应的危险因素分析

Analysis on risk factors of adverse events after non-sedated esophagogastroduo-denoscopy

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