中医五行人之木行人与金行人兴奋-抑制平衡的比较研究

doi:10.3969/j.issn.1006-7795.2026.03.017

首都医科大学学报 ›› 2026, Vol. 47 ›› Issue (3): 541-548.doi: 10.3969/j.issn.1006-7795.2026.03.017

• 精神科中西医结合临床及认知神经基础 • 上一篇下一篇

中医五行人之木行人与金行人兴奋-抑制平衡的比较研究

林锦^1，2,贾竑晓^1，2*#,吕宏蓬^1，2*#,戴芷晴^1，2,姜新月³,徐欢舒^1，2,赵子怡^1，2,张云河⁴

1.首都医科大学附属北京安定医院国家精神疾病医学中心精神心理疾病国家临床医学研究中心精神疾病创新药智能研发北京市重点实验室，北京 100088；2.人脑保护高精尖创新中心，首都医科大学，北京 100069；3.北京中医药大学第三临床医学院，北京 100029；4.赤峰市精神病防治院，内蒙古赤峰 024200

收稿日期:2026-02-02 修回日期:2026-03-09 出版日期:2026-06-21 发布日期:2026-06-26
通讯作者: 贾竑晓, 吕宏蓬 E-mail:jhxlj@ccmu.edu.cn,molly731@126.com
基金资助:
国家自然科学基金项目（82305193，82474429），首都医科大学临床-基础合作平台培育项目（JLPYPT2025002），首都卫生发展科研专项（首发2026-2-2124），北京中医药薪火传承“新3+3”工程示范案例项目（2023-ZYSF-19）。

A study on the differences in excitation-inhibition balance between Wood Element and Metal Element individuals among the Traditional Chinese Medicine Five Element people

Lin Jin^1，2, Jia Hongxiao^1，2*#, Lü Hongpeng^1，2*#, Dai Zhiqing^1，2, Jiang Xinyue³, Xu Huanshu^1,2, Zhao Ziyi^1,2, Zhang Yunhe⁴

1.Beijing Anding Hospital, Capital Medical University；National Center for Mental Disorders；National Clinical Research Center for Mental Disorders；Beijing Key Laboratory of Intelligent Drug Research and Development for Mental Disorders， Beijing 100088, China; 2. Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100069, China;3. Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, China; 4. Chifeng Psychiatric Hospital,Chifeng 024200， Inner Mongolia Autonomous Region，China

Received:2026-02-02 Revised:2026-03-09 Online:2026-06-21 Published:2026-06-26
Supported by:
This study was supported by National Natural Science Foundation of China(82305193，82474429), Capital Medical University Clinical-Basic Cooperation Platform Cultivation Project(JLPYPT2025002),Capital Health Development Scientific Research Special Project (2026-2-2124), Beijing Traditional Chinese Medicine Inheritance “New 3+3” Program Demonstration Case Project（2023-ZYSF-19）.

摘要/Abstract

摘要： 目的基于脑电功能性兴奋-抑制比指标，比较木行人与金行人在兴奋-抑制平衡上的差异。从神经电生理角度探索中医五行人中木行人与金行人的功能调控特征。方法根据前期制订的《中医五行（形）人面部表型分类量化规范》，招募典型的木行人与金行人，采集闭眼静息态脑电图，将电极划分为前额叶、额叶、中央区、顶叶、颞叶、枕叶6个脑区；频段划分为theta（4~8 Hz）、alpha（8~13 Hz）、lower beta（13~19 Hz）、high beta（19~30 Hz）及gamma（30~45 Hz）。计算各频段功率谱密度（power spectral density，PSD）与功能性兴奋-抑制比（functional excitation-inhibition, fEI），并在全脑与脑区层面进行组间比较，采用Bonferroni校正控制多重比较。结果木行人与金行人分别纳入30例。全脑层面，各频段PSD差异均无统计学意义；全脑fEI在theta、alpha及lower beta频段木行人均显著高于金行人，而high beta与gamma频段差异无统计学意义。脑区层面，theta频段枕叶木行人fEI值大于金行人；alpha频段前额叶、额叶、中央区、顶叶及枕叶木行人fEI值大于金行人。结论木行人与金行人在神经活动层面呈现出具有频段特异性的兴奋-抑制调控差异，反映了不同中医五行人在大脑功能调控方式上的差别。

关键词: 中医五行人, 脑电, 兴奋抑制平衡, 功能性兴奋-抑制比, 神经电生理, 中医心理学

Abstract: Objective To compare excitation-inhibition (E/I) balance between Wood Element and Metal Element individuals by using the electroencephalography (EEG) derived functional excitation-inhibition ratio (fEI), and to investigate their functional regulatory characteristics from a neuroelectrophysiological perspective within the Traditional Chinese Medicine (TCM) Five Element typology. Methods Typical Wood Element and Metal Element participants were recruited according to the previously established Quantitative Specification for Facial Phenotype Classification of TCM Five Element (Morphological) Types. Resting-state, eyes-closed EEG was recorded. Electrodes were grouped into six regions of interest: prefrontal, frontal, central, parietal, temporal, and occipital. Frequency bands were defined as theta (4-8 Hz), alpha (8-13 Hz), lower beta (13-19 Hz), high beta (19-30 Hz), and gamma (30-45 Hz). Power spectral density (PSD) and fEI were calculated for each band. Group comparisons were conducted at both whole-brain and regional levels, with Bonferroni correction applied for multiple comparisons. Results Thirty participants were included in each group. At the whole-brain level, no significant differences in PSD were observed across frequency bands. Whole-brain fEI values in the theta, alpha, and lower beta bands were significantly higher in the Wood Element group than in the Metal Element group, whereas no significant differences were found in the high beta or gamma bands. At the regional level, occipital fEI in the theta band was higher in the Wood Element group than in the Metal Element group; in the alpha band, fEI values in the prefrontal, frontal, central, parietal, and occipital regions were also higher in the Wood Element group than in the Metal Element group. Conclusion Wood Element and Metal Element individuals exhibit frequency-specific differences in E/I regulation at the neural activity level, indicating distinct patterns of brain functional regulation across TCM Five Element types.

Key words: Traditional Chinese Medicine Five Element people, electroencephalography, excitation-inhibition balance, functional excitation-inhibition ratio, neuroelectrophysiology, Traditional Chinese Medicine psychology

中图分类号:

林锦, 贾竑晓, 吕宏蓬, 戴芷晴, 姜新月, 徐欢舒, 赵子怡, 张云河. 中医五行人之木行人与金行人兴奋-抑制平衡的比较研究[J]. 首都医科大学学报, 2026, 47(3): 541-548.

Lin Jin, Jia Hongxiao, Lü Hongpeng, Dai Zhiqing, Jiang Xinyue, Xu Huanshu, Zhao Ziyi, Zhang Yunhe. A study on the differences in excitation-inhibition balance between Wood Element and Metal Element individuals among the Traditional Chinese Medicine Five Element people[J]. Journal of Capital Medical University, 2026, 47(3): 541-548.

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中医五行人之木行人与金行人兴奋-抑制平衡的比较研究

A study on the differences in excitation-inhibition balance between Wood Element and Metal Element individuals among the Traditional Chinese Medicine Five Element people

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