哮喘儿童血清变应原特异性IgE分布特征

首都医科大学学报 ›› 2005, Vol. 26 ›› Issue (5): 577-581.

哮喘儿童血清变应原特异性IgE分布特征

向莉, 熊珍谊, 任亦欣

首都医科大学附属北京儿童医院儿科研究所呼吸功能室

收稿日期:2005-08-20 修回日期:1900-01-01 出版日期:2005-10-24 发布日期:2005-10-24

Distribution Characteristics of Allergen-specific Serum IgE Antibodies in Asthma Children

Xiang Li, Xiong Zhenyi, Ren Yixin

Respiratory Laboratory, Pediatric Research Institute, Beijing Children's Hospital, Capital University of Medical Sciences

Received:2005-08-20 Revised:1900-01-01 Online:2005-10-24 Published:2005-10-24

摘要/Abstract

摘要：

目的观察临床诊断为哮喘的儿童血清变应原特异性IgE(sIgE)的分布特征。方法应用UniCAP100系统的荧光酶联免疫方法,对临床确诊的324例哮喘儿童和60例无特应性疾病史的对照组儿童进行吸入性变应原筛查(Phadiatop)和食物变应原筛查(fx5E),比较2组筛查阳性率的差异,并分析哮喘组各年龄段的筛查阳性率。对其中94例Phadiatop阳性哮喘儿童选择性测定8种(类)吸入性变应原血清sIgE,包括户尘螨、粉尘螨、屋尘、混合真菌、混合树木花粉、混合草花粉、猫毛发皮屑、狗毛发皮屑,分析各种(类)吸入性变应原阳性检出率。结果 324例哮喘组儿童Phadiatop、fx5E阳性率分别为55.2%和45.1%,均显著高于对照组相应阳性率20.0%和23.3%。单纯Phadiatop阳性的哮喘儿童平均年龄(7.47±3.27)岁,显著高于单纯fx5E阳性哮喘儿童的平均年龄(3.80±2.04)岁。哮喘儿童Phadiatop阳性的高峰年龄段分别在7岁(总阳性率86.4%)和10岁(总阳性率83.3%)。fx5E阳性的高峰年龄段为3岁(总阳性率63.2%)。94例哮喘儿童血清sIgE阳性检出率分别为:户尘螨62.7%、粉尘螨61.7%、屋尘58.5%、混合真菌43.6%、混合树木花粉27.7%、混合草花粉26.6%、猫毛发皮屑47.6%、狗毛发皮屑36.0%。结论临床诊断为哮喘的儿童,近75%对吸入性变应原和(或)食物变应原过敏;婴幼儿期哮喘儿童以食物性变应原过敏多见,4岁以上哮喘儿童对吸入性变应原过敏逐渐增加。在吸入性变应原中,尘螨、屋尘和真菌是引起儿童哮喘主要的变应原。

关键词: 哮喘, 儿童, 变应原, 特异性IgE

Abstract:

Objective To investigate distribution characteristics of allergen-specific serum IgE antibodies in clinical diagnostic asthma children.Methods Inhalant and food allergen-specific serum IgE antibodies were determined in 324 asthma children and 60 non-atopic control children by fluoroenzyme-immunometric assay,UniCAP100,applying the Phadiatop and fx5E testing.We compared the positive ratio of Phadiatop and fx5E between the two groups and computed the positive ratio of Phadiatop among different age groups of asthma children.Eight kinds of inhalant specific IgE antibodies against Dermatophagoids pteronyssinus,Dermatophagoids farinae,house dust,mixed molds,mixed tree pollen,mixed grass pollen,cat and dog dander were selected tested in 94 asthma children with positive phadiatop test,the positive ratio of each inhalant allergen was reported.Results The positive ratio of Phadiatop and fx5E in 324 asthma children were 55.2% and 45.1% respectively,which were significantly higher than that of control group.The mean age of asthma children with mere positive reaction to Phadiatop was significantly older than that of asthma children with mere positive reaction to fx5E((7.47±3.27)year vs(3.80±2.04)year).The highest positive ratio of Phadiatop was 86.4% and 83.3% in 7 and 10 years of age asthma children respectively.The positive ratio of each inhalant allergen specific serum IgE antibody in 94 asthma chidren was that: Dermatophagoids pteronyssinus 62.7%,Dermatophagoids farinae 61.7%, house dust 58.5%,mixed molds 43.6%,mixed tree pollen 27.7%,mixed grass pollen 26.6%,cat dander 47.6%,dog dander 36.0%.Conclusion About 75% clinical diagnostic asthma children presented inhalant and/or food allergen sensitization.Dermatophagoids,house dust and molds were the main inhalatnt allengens in asthma children.Asthma infants mainly manifested food allergen sensitization,but the prevalence of sensitization to inhalant allergen increased in up to 4-year-old asthma children.

Key words: asthma, children, allergen, sIgE

中图分类号:

R725.6

向莉;熊珍谊;任亦欣. 哮喘儿童血清变应原特异性IgE分布特征[J]. 首都医科大学学报, 2005, 26(5): 577-581.

Xiang Li;Xiong Zhenyi;Ren Yixin. Distribution Characteristics of Allergen-specific Serum IgE Antibodies in Asthma Children[J]. Journal of Capital Medical University, 2005, 26(5): 577-581.

[1]	李艳, 王麒淇, 张宇玲, 段甦, 张海波, 王向东, 蓝凤. 不同体质量指数的慢性鼻窦炎伴鼻息肉患者临床特征分析[J]. 首都医科大学学报, 2022, 43(6): 899-904.
[2]	李昂, 皇惠杰, 杨世青, 侯晓玲, 向莉. 长程治疗管理哮喘儿童的肺功能轨迹特征分析[J]. 首都医科大学学报, 2022, 43(6): 940-947.
[3]	夏宁, 聂秀红, 王昊, 樊晓君. 支气管哮喘合并OSA与冠心病发病率的相关性研究[J]. 首都医科大学学报, 2022, 43(1): 138-142.
[4]	吴鸿波, 李曼曼, 林丽丽, 李丽华. 单中心儿科门急诊0~16岁儿童10年死亡数据分析[J]. 首都医科大学学报, 2021, 42(5): 852-856.
[5]	马佳佳, 岳红丽, 王德祥, 金旭, 韩如泉. 不同剂量右美托咪定对儿童颅脑术后苏醒期躁动的影响[J]. 首都医科大学学报, 2021, 42(3): 459-463.
[6]	王振民, 宫剑. 儿童开颅术后脑脊液外引流与颅内感染的相关性研究[J]. 首都医科大学学报, 2021, 42(2): 269-272.
[7]	弓雪峰, 任培中, 崔红生, 姜振远, 张诗瑜, 王佳美, 张馨予, 陈秋仪, 吕明圣, 候丹. 基于网络药理学探讨哮喘宁颗粒防治心理应激哮喘的作用网络与潜在机制[J]. 首都医科大学学报, 2020, 41(4): 576-589.
[8]	段超, 王生才, 金眉, 张大伟, 赵文, 王希思, 赵倩, 邰隽, 张杰, 何乐建, 张建国, 倪鑫, 马晓莉. 儿童头颈部非横纹肌肉瘤软组织肉瘤临床研究[J]. 首都医科大学学报, 2019, 40(6): 921-926.
[9]	贾晨光, 周翾, 王彬, 朱光华, 秦茂权. 异基因造血干细胞移植治疗儿童急性髓系白血病的临床观察[J]. 首都医科大学学报, 2019, 40(2): 163-168.
[10]	王希思, 杨维, 黄程, 赵文, 赵倩, 段超, 苏雁, 金眉, 张大伟, 秦红, 王焕民, 马晓莉. 儿童肝母细胞瘤的临床特征和治疗效果评价[J]. 首都医科大学学报, 2019, 40(2): 169-173.
[11]	张利强, 陈振萍, 郑杰, 马洁, 吴润晖. 国产甲磺酸伊马替尼治疗儿童慢性髓系白血病慢性期的早期疗效和安全性分析[J]. 首都医科大学学报, 2019, 40(2): 174-178.
[12]	张金, 任思其, 李舒婷, 李苗, 龚小军, 孙艳玲, 武万水, 孙黎明, 杜淑旭. 脑脊液肿瘤坏死因子-α和干扰素-γ对髓母细胞瘤患儿的预后评价分析[J]. 首都医科大学学报, 2019, 40(2): 201-204.
[13]	张利强, 郑杰, 马洁, 陈振萍, 吴润晖. 9例具有致病基因变异的儿童期原发性血小板增多症临床分析[J]. 首都医科大学学报, 2018, 39(4): 607-611.
[14]	李莹, 祁森荣, 华琳, 尚佳健. 儿童复发性腮腺炎患者与正常儿童腮腺液微生物群落多样性的差异[J]. 首都医科大学学报, 2018, 39(3): 453-457.
[15]	李文风, 文宏伟, 刘玥, 彭芸, 程华, 李宏彬, 邰隽. 弥散峰度成像对儿童阻塞性睡眠呼吸暂停综合征脑微结构变化的研究[J]. 首都医科大学学报, 2018, 39(2): 178-184.