伯喹对疟原虫的配子体、配子生殖和孢子增殖的影响

首都医科大学学报 ›› 1989, Vol. 10 ›› Issue (2): 95-100.

伯喹对疟原虫的配子体、配子生殖和孢子增殖的影响

陈佩惠¹, 时云林², 杨俊德²

1. 首都医学院寄生虫学教研室;2. 军事医学科学院微生物流行病研究所

收稿日期:1988-07-20 修回日期:1900-01-01 出版日期:1989-04-15 发布日期:1989-04-15

Effect of Primaquine on the Gametocyte, Gametogony and Sporogony of Malaria Parasite

Chen Peihui¹, Shi Yunling², Yang Junde²

1. Department of Parasitology, Capital Institute of Medicine;2. Institute of Microbiology and Epidemiology of Chinese Military Academy of Medical Seiene

Received:1988-07-20 Revised:1900-01-01 Online:1989-04-15 Published:1989-04-15

摘要/Abstract

摘要： 给感染约氏疟原虫尼日利亚亚种的小鼠灌服怕喹1.25mg/kg和1.95mg/kg8h后,小鼠血内配子体数可减少一半,有些配子体胞质出现空泡,甚至虫体变小,随着伯喹剂量的增加与延长药后感染蚊虫的时间,形成动合子的数量,卵囊的感染率、感染度以及子孢子进腺率均降低;同时显示伯喹可致动合子和卵囊的形态结构发生变异,胞质出现空泡,虫体收缩等。在给药1.25mg/kg后8h,1.95mg/kg后4h,2.5mg/kg和5mg/kg后2h感染蚊媒,均未见子孢子进腺。证实伯喹既可作用于疟原虫配子体,又可影响其配子生殖和孢子增殖。

关键词: 约氏疟原虫尼日利亚亚种, 配子体, 卵囊, 子孢子, 伯喹

Abstract: The Plasmodium yoelii nigeriensis gametocyte carrying mice were administered intragastrically with primaquiue 1.25mg/kg and 1.95mg/kg, 8h after treatment, the number of gametocytes in the blood had been reduced to 1/2. The morphology of some gametocytes appeared abnormal. The decrease of number of ookinetes, the infective rate and infetive degree of oocysts and gland infection rate was proportional to the increase of dosage of primaquine and infection time of mosquitoes, with the vacuolation and shri nkage of some ookinetes and oocysts.

Key words: Plasmodium yoelii nigeriensis, gametocyte, ookinete, oocyst, sporozoite, primaquine

陈佩惠;时云林;杨俊德. 伯喹对疟原虫的配子体、配子生殖和孢子增殖的影响[J]. 首都医科大学学报, 1989, 10(2): 95-100.

Chen Peihui;Shi Yunling;Yang Junde. Effect of Primaquine on the Gametocyte, Gametogony and Sporogony of Malaria Parasite[J]. Journal of Capital Medical University, 1989, 10(2): 95-100.

[1]	陈佩惠;时云林. 约氏疟原虫尼日利亚亚种的卵囊与附属囊的形态观察[J]. 首都医科大学学报, 1990, 11(3): 164-167.
[2]	邵平;孔德芳;王瑞芳. MP0090对约氏鼠疟原虫孢子增殖期作用的透射电镜初步观察[J]. 首都医科大学学报, 1988, 9(3): 174-178.
[3]	诸欣平;孔德芳;王瑞芳. 应用Feulgen染色及显微分光光度计探讨乙胺嘧啶对约氏疟原虫卵囊的作用机理[J]. 首都医科大学学报, 1987, 8(4): 280-282.