首都医科大学学报 ›› 1990, Vol. 11 ›› Issue (1): 48-50.

• 论著 • 上一篇    下一篇

大鼠心室心钠素的分布及其与月龄的关系

温绍君, 汪家瑞, 何士大, 徐宝钢, 黄丽君, 陈建军, 于仲元, 洪方裕   

  1. 首都医学院宣武医院高血压研究室
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1990-01-15 发布日期:1990-01-15

Distribution of the Rat Ventricular Atrial Natriuretic Factor and Correlation with Months

Wen Shaojun, Wang Jiarui, He Shida   

  1. Hypertension Research Lab Xuanwu Hospital Capital Institute of Medicine
  • Received:1900-01-01 Revised:1900-01-01 Online:1990-01-15 Published:1990-01-15

摘要: 选用雌性Wistar大鼠,分为5个月龄组,取心脏后分别制备心室不同部位心肌组织匀浆,经分离提取后应用直接放射免疫法测定心室心钠素。其结果为:心室不同部位心钠素呈特异性分布,心室间隔心钠素与月龄呈显著负相关,提示在心脏老化过程中,随月龄增加,心脏某些重要内分泌功能逐渐减退。

关键词: 老化, 心室, 心钠素

Abstract: Female wistar rats were segregated into 5 groups (1, 8, 6, 10, 21months), the 21-month group was taken as ageing rats. Myocardial homogenates were prepared. The ventricular ANF levels in different parts of the myocardium were measured by RIA, As a result, ANF has a characteristic distribution in different parts of the ventricle. There is a negative correlation between the intraval-ventricular ANF and months. The experiment suggests that as age increases, the cardiac some important hormonal function diminishes during the heart ageing.

Key words: ageing, ventricle, ANF