大鼠应激性溃疡与胃泌素、胰高血糖素和生长抑素的相关性研究

首都医科大学学报 ›› 1995, Vol. 16 ›› Issue (4): 287-289.

大鼠应激性溃疡与胃泌素、胰高血糖素和生长抑素的相关性研究

梁丕霞¹, 杨昭徐¹, 张绍东², 吴建中²

1. 首都医学院附属北京天坛医院内科消化组;2. 北京市神经外科研究所

收稿日期:1994-11-07 修回日期:1900-01-01 出版日期:1995-10-15 发布日期:1995-10-15

A Study on Links of Stress Ulcer and the Serum Levels of Gastrin Glucagon and Somatostatin in Rats

Liang Peixia¹, Yang Zhaoxu¹, Zhang Shaodong², Wu Jianzhong²

1. Department of Gastroenterology, Beijing Tiantan Hospital, Capital Institute of Medicine;2. Beijing Neurosurgical Institute

Received:1994-11-07 Revised:1900-01-01 Online:1995-10-15 Published:1995-10-15

摘要/Abstract

摘要： 采用冷束缚法建立大鼠应激性溃疡模型,以探讨胃肠激素与应激性溃疡发病的相关性。实验组置于(4±2)℃环境,3H,对照组置于(18±3)℃,3h,分别检测不同时间血清胃泌素、胰高血糖素、生长抑素的水平。结果表明,实验组胃泌素、胰高血糖素水平明显高于对照组,生长抑素水平明显低于对照组。提示胃泌素、胰高血糖素、生长抑素可能从不同的角度参与了应激性溃疡的消长过程。

关键词: 应激性溃疡, 胃泌素, 胰高血糖素, 生长抑素

Abstract: This article deals with the links between three gastrointestino-hormones and irritable ulcer in“cold-ties”induced ulcer model.Our experiment indicated that: ①The serum gastrin levels of the stress group were significantly higher than that of the control.This might be due o the excitement of vagus nerve under stress.② The serum levels of somatostatin in stress group were lower than that of the control ,this indicated that the inhibihition of somatostatin in gastro-secretin was reduced which in turn caused hyperhydrochloria.③The serumglucagon correlated positively with serum gastrin level and negatively with blood sugar.These peptides might function as gastrointestinal hormones and neurotransmitters in the CNSand peripheral nervous system.

Key words: stress ulcer, gastrin, glucagon, somatostatin

中图分类号:

R573.1

梁丕霞;杨昭徐;张绍东;吴建中. 大鼠应激性溃疡与胃泌素、胰高血糖素和生长抑素的相关性研究[J]. 首都医科大学学报, 1995, 16(4): 287-289.

Liang Peixia;Yang Zhaoxu;Zhang Shaodong;Wu Jianzhong. A Study on Links of Stress Ulcer and the Serum Levels of Gastrin Glucagon and Somatostatin in Rats[J]. Journal of Capital Medical University, 1995, 16(4): 287-289.

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