急性重症感染并发弥漫性血管内凝血的实验诊断

首都医科大学学报 ›› 1996, Vol. 17 ›› Issue (2): 116-120.

急性重症感染并发弥漫性血管内凝血的实验诊断

刘贵健, 王宝恩, 赵淑芳, 李天潢, 张淑文

首都医科大学附属北京友谊医院

收稿日期:1995-05-12 修回日期:1900-01-01 出版日期:1996-04-15 发布日期:1996-04-15

Study on Laboratory Diagnosis of DIC during Severe Infection

Liu Guijian, Wang Bao'en, Zhao Shufang, Li Tianhuang, Zhang Shuwen

Beijing Friendship Hospital, Capital University of Medical Sciences

Received:1995-05-12 Revised:1900-01-01 Online:1996-04-15 Published:1996-04-15

摘要/Abstract

摘要： 对50例急性重症感染病人(24例合并DIC,26例未合并DIC)做了凝血酶原时间(PT)、活化的部分凝血活酶时间(APTT)、纤维蛋白原含量(Fg)、血小板数量(Plt)、抗凝血Ⅲ(AT-Ⅲ)、纤溶酶原活性(PLG)、α₂纤溶酶活性(α₂AP)和D-二聚体含量(D-Dimer)8种凝血纤溶指标的测定观察。结果表明：DIC在感染性多系统脏器衰竭(MSOF)的发生发展过程中具有重要作用。单次Fg含量测定对感染性DIC的诊断价值不大。PT、APTT、AT-Ⅲ、PLG、Plt、D-Dimer和α₂AP可做为感染性DIC的实验诊断指标,但单项测定对DIC的诊断率均未超过80%,而多项指标的联合检测可提高诊断率至90%以上。

关键词: 急性重症感染, 弥漫性血管内凝血, 实验诊断, 纤溶系统, 凝血系统

Abstract: Fifty cases of patients with acute severe infection (24 cases with DIC and 26 cases with out DIC) were studied and prothrombin time (PT), activated partial thromboplastin time (APTT),fibrinogen(Fg) concentration,platelet (PLT) count,anti-thrombin Ⅲ (AT-Ⅲ) activity,plasminogen (PLG) activity, α₂-antiplasmin (α₂AP) activity,D-Dimer concentration in plasma were examined.The results suggested that DIC was the important causes for the pathogenesis and development of MSOF.The single detection data of Fg had no more diagnostic importance in infectious DIC, PT,APTT,Plt, AT-Ⅲ, PLG, α₂-AP, D-Dimer were all helpfull laboratory parameters for diagnosing DIC.The diagnostic rate of DIC by using a single parameter was less than 80 percent, the diagnostic rate of DIC by using combined multiple parameters was more than 90 percent.

Key words: acute severe infection, disseminated intravascular coagulation, laboratory diagnosis, coagulation system, fibrinolytic system

中图分类号:

R554.8

刘贵健;王宝恩;赵淑芳;李天潢;张淑文. 急性重症感染并发弥漫性血管内凝血的实验诊断[J]. 首都医科大学学报, 1996, 17(2): 116-120.

Liu Guijian;Wang Bao'en;Zhao Shufang;Li Tianhuang;Zhang Shuwen. Study on Laboratory Diagnosis of DIC during Severe Infection[J]. Journal of Capital Medical University, 1996, 17(2): 116-120.

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