首都医科大学学报 ›› 1997, Vol. 18 ›› Issue (3): 242-245.

• 论著 • 上一篇    下一篇

颅脑疾患术后肾缺血引起尿中表皮生长因子变化的研究

齐慧敏   

  1. 首都医科大学附属北京天坛医院心肾内科
  • 收稿日期:1996-10-11 修回日期:1900-01-01 出版日期:1997-07-15 发布日期:1997-07-15

Research on Changes in Urinary EGF after Craniocerebral Operations

Qi Huimin   

  1. Department of Cardiovascular and Renal Internal Medical, Beijing Tiantan Hospital, Affiliate of Capital University of Medical Sciences
  • Received:1996-10-11 Revised:1900-01-01 Online:1997-07-15 Published:1997-07-15

摘要: 观察了垂体瘤和小脑幕下肿瘤及脑外伤术后病人尿中表皮生长因子(EGF)的变化,尿中糖、N乙酰β氨基葡萄糖苷酶(NAG)、尿酸(Ua)、尿γ-谷氨酰转移酶(γ-GT)的变化,血浆肾素活性(PRA)、血管紧张素Ⅰ和Ⅱ(ANGⅠ和Ⅱ)的变化,以及内生肌酐清除率(Ccr)、渗透溶质分子清除率(Cosm)的变化。结果脑疾患术后尿EGF排出量及尿Ua与正常对照组比较明显降低(P<0.01),Ccr与正常对照组比较无显着性差异(P>0.05),PRA、ANGⅠ、ANGⅡ、Cosm及尿中糖、NAG、γ-GT的排出量与正常对照组比较明显升高(P<0.05或<0.01).尿EGF与尿NAG、γ-GT呈负相关(P<0.05).

关键词: 表皮生长因子, 肾素活性, 血管紧张素, N-乙酰β-氨基葡萄糖苷酶, γ-谷氨酰转移酶, 脑外伤, 脑肿瘤

Abstract: Changes in PRA,ANGⅠ,ANGⅡ,urinary EGF,sugar,NAG,Ua,and γ-GT excreation of patients after operations of hypophysoma and tumor under cerebellar tentorium and brain trauma were observed in this article.PRA,ANGⅠ,ANGⅡ,urinary sugar,NAG,γ-GT excreation rose in contrast with control( P<0.05 or < 0.01 ).Urinary EGF, Ua excreation fell in contrast with control( P< 0.01 ).Urinary EGFwas negatively correlated to urinaty NAG,γ-GT( P<0.05).

Key words: epidermal growth factor, plasma renin activity, angiotensin, β-N-acetylglucosaminidase, glutamyltransferase, brain trauma, brain tumor

中图分类号: