Ang(1-7)通过调节内质网应激改善骨骼肌脂代谢及胰岛素抵抗

doi:10.3969/j.issn.1006-7795.2018.04.010

摘要/Abstract

摘要： 骨骼肌胰岛素抵抗在2型糖尿病发病中起到重要作用，血管紧张素可通过内质网应激机制改善骨骼肌脂代谢，从而改善胰岛素抵抗。近年来研究探索了内质网应激的具体分子机制，本文主要讨论了血管紧张素通过内质网应激对骨骼肌脂代谢及胰岛素抵抗的影响及其可能的机制。

关键词: 血管紧张素, 内质网应激, 骨骼肌脂代谢, 胰岛素抵抗

Abstract: Insulin resistance of skeletal muscle plays an important role in the pathogenesis of type 2 diabetes. Angiotensin can improve skeletal muscle lipid metabolism through endoplasmic reticulum stress and thus improve insulin resistance. In recent years, the specific molecular mechanism of endoplasmic reticulum stress has been explored. This paper mainly discusses the effect of endoplasmic reticulum stress on the lipid metabolism and insulin resistance of skeletal muscle and the possible mechanism.

Key words: angiotensin, endoplasmic reticulum stress, skeletal muscle lipid metabolism, insulin resistance

中图分类号:

R587.1

鹿星梦, 信中. Ang(1-7)通过调节内质网应激改善骨骼肌脂代谢及胰岛素抵抗[J]. 首都医科大学学报, 2018, 39(4): 532-536.

Lu Xingmeng, Xin Zhong. Ang (1-7) improves skeletal muscle lipid metabolism and insulin resistance by regulating endoplasmic reticulum stress[J]. Journal of Capital Medical University, 2018, 39(4): 532-536.

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