追赶生长与阿尔茨海默病相关性

doi:10.3969/j.issn.1006-7795.2017.06.011

首都医科大学学报 ›› 2017, Vol. 38 ›› Issue (6): 831-834.doi: 10.3969/j.issn.1006-7795.2017.06.011

• 神经系统疾病的基础和临床研究 • 上一篇下一篇

追赶生长与阿尔茨海默病相关性

金贺, 赵志炜, 王蓉

首都医科大学宣武医院中心实验室北京市老年医疗研究中心北京脑重大疾病研究院神经变性病教育部重点实验室, 北京 100053

收稿日期:2017-10-01 出版日期:2017-11-21 发布日期:2017-12-16
通讯作者: 王蓉 E-mail:rong_wang72@aliyun.com
基金资助:
国家重点研发计划（2016YFC1306300），首都医学发展专项（2014-1-1031）。

Correlation between catch up growth and Alzheimer's disease

Jin He, Zhao Zhiwei, Wang Rong

Central Laboratory, Xuanwu Hospital, Capital Medical University, Beijing Geriatric Medical Research Center, Beijing Institute for Brain Disorders, Key Laboratory for Neurodegenerative Disease, Ministry of Education, Beijing 100053, China

Received:2017-10-01 Online:2017-11-21 Published:2017-12-16
Supported by:
This study was supported by National Key Research Development Program(2016YFC1306300), Capital Health Research and Development of Special(2014-1-1031).

摘要/Abstract

摘要： 阿尔茨海默病（Alzheimer's disease，AD）的病因、发病机制十分复杂，涉及与遗传和环境相互作用有关的诸多因素。其中，与追赶生长相伴随的胰岛素抵抗、能量代谢异常、氧化应激、炎性反应、自噬过程改变等是AD发病机制中被广泛认可的危险因素。本文结合近年来对追赶生长现象的研究，探讨其与AD之间的潜在关系。

关键词: 追赶生长, 阿尔茨海默病, 胰岛素抵抗, 能量代谢异常, 氧化应激, 自噬

Abstract: The etiology and pathogenesis of Alzheimer's disease is complex and involves many factors related to the interaction of genetic and environmental. Among them, the insulin resistance, abnormal energy metabolism, oxidative stress, inflammatory response and changes in autophagy process with catch up growth are widely recognized as risk factors of Alzheimer's disease.This article focuses studies on the catch up growth phenomenon in recent years, try to explore its potential relationship with Alzheimer's disease.

Key words: catch up growth, Alzheimer's disease, insulin resistance, abnormal energy metabolism, oxidative stress, autophagy

中图分类号:

金贺, 赵志炜, 王蓉. 追赶生长与阿尔茨海默病相关性[J]. 首都医科大学学报, 2017, 38(6): 831-834.

Jin He, Zhao Zhiwei, Wang Rong. Correlation between catch up growth and Alzheimer's disease[J]. Journal of Capital Medical University, 2017, 38(6): 831-834.

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追赶生长与阿尔茨海默病相关性

Correlation between catch up growth and Alzheimer's disease

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