首都医科大学学报 ›› 2001, Vol. 22 ›› Issue (4): 337-339.

• 论著 • 上一篇    下一篇

影响糖尿病患者肾小球滤过率危险因素的分析

傅汉菁1, 袁申元1, 朱良湘1, 戴浩洁2   

  1. 1. 首都医科大学附属北京同仁医院内分泌科;2. 同仁医院核医学科
  • 收稿日期:2000-09-05 修回日期:1900-01-01 出版日期:2001-10-15 发布日期:2001-10-15

Multiple Factor Analysis on Glomerular Filtration Rate in Type 2 Diabetes Mellitus

Fu Hanjing1, Yuan Shenyuan1, Zhu Liangxiang1, Dai Haojie2   

  1. Dept. of Endocrinology, Beijing Tongren Hospital, Affiliate of Capital University of Medical Sciences
  • Received:2000-09-05 Revised:1900-01-01 Online:2001-10-15 Published:2001-10-15

摘要: 为探讨各种危险因素对糖尿病患者肾小球滤过率(GFR)的影响,应用多元逐步回归方法对214例2型糖尿病患者有关GFR的危险因素进行分析.结果:①GFR下降组的年龄、病程、高血压史、冠心病史、视网膜病变患病率、腰臀围比值均明显高于GFR正常组(P<0.01).②2组的GFR、尿素氮、肌酐和尿白蛋白的对数值均有显着性差异(P<0.01).③多因素回归分析显示:影响糖尿病病人GFR的主要因素依次为年龄、肌酐、视网膜病变、高血压史和尿素氮.提示:为早期预防糖尿病肾病,除了要有效控制血糖外,还要严格控制血压和积极防治视网膜病变.

关键词: 2型糖尿病, 肾小球滤过率, 多因素分析

Abstract: To evaluate the importance of different risk factors and their mutual interactions on glomerular filtration rat(GFR)in type 2 diabetes mellitus, an investigation was carried out on the relationship between GFR and various risk factors in 214 cases of type 2 diabetes by way of stepwise regression analysis method. Results: ① The average age, DM course, waist/hip-ratio, hypertension prevalence, coronary heart disease prevalence and diabetic retinopathy prevalence were higher in GFR dropped group than that of GFR normal group(P<0.01). ② The values of GFR, BUN, Scr, UAER were significant difference between two groups(P<0.01). ③ Multiple backward regression analysis showed that age, Scr, diabetic retinopathy, hypertension and BUN were independent risk factors for GFR. Conclusion: To dealy the decrease of GFR and prevent the occurrence of diabetic nephropathy, it is important not only to control blood sugar, but also to control blood pressure and relieve diabetic retinopathy.

Key words: type 2 diabetes mellitus, glomerular filtration rate, multiple factor analysis

中图分类号: