首都医科大学学报 ›› 2001, Vol. 22 ›› Issue (1): 62-64.

• 论著 • 上一篇    下一篇

地氟醚吸入麻醉在神经外科手术中的应用

陈新忠, 罗芳, 王保国   

  1. 首都医科大学附属北京天坛医院麻醉科
  • 收稿日期:2000-08-25 修回日期:1900-01-01 出版日期:2001-01-15 发布日期:2001-01-15

Desflurane Inhalation Anesthesia Used for Neurosurgery

Chen Xinzhong, Luo Fang, Wang Baoguo   

  1. Department of Anesthesiology, Beijing Tiantan Hospital, Affiliate of Capital University of Medical Sciences
  • Received:2000-08-25 Revised:1900-01-01 Online:2001-01-15 Published:2001-01-15

摘要: 为观察不同维持体积分数地氟醚吸入麻醉与脑电图双频谱指数(BIS)和95%边缘频率(SEF)、血流动力学之间的关系,探讨适合神经外科手术的吸入麻醉深度.将36例ASAⅠ~Ⅱ级无明显颅内压增高的神经外科择期手术病人,随机分成0.7MAC(最低肺泡有效浓度)(4.2%)、1.0MAC(6.0%)、1.3MAC(7.8%)3组(每组12例),监测基础值、诱导后、吸入前、达MAC标点、维持30、60、90、120、150、180min、停止吸入时、拔管、呼唤睁眼、指令恢复、定向力恢复时的平均动脉压(MAP)、心率(HR)、BIS、SEF的变化及术后恢复情况.结果:地氟醚吸入的体积分数与BIS、SEF呈剂量相关.1.0MAC组麻醉平稳,辅助用药少,麻醉恢复快,用于神经外科手术是安全可靠的.

关键词: 神经外科, 地氟醚, 脑电图双频谱指数, 边缘频率

Abstract: Relations between the maintenance concentration of desflurane, BIS, SEF and hemodynamics were evaluated in order to select a suitable inhalation concentration in neurosurgery. Thirty-six patients, ASA gradeⅠ to Ⅱ, undergoing neurosurgery were divided into three groups: 0.7 MAC(4.2 %), 1.0 MAC(6.0%)and 1.3 MAC(7.8%)with 12 cases each. MAP, HR, BIS and SEF were measured before induction,after induction, before inhalation at the predetermined MAC at maintenance 30, 60, 90, 120, 150, 180 min, stopping inhalation, extubation, opening eyes, following commands and oriential recovery, respectively. Desflurane inhalation concentrations had good dose-relationship with BIS and SEF. Hemodynamics was stable in 1.0 MAC group with faster recovery. 1.0 MAC of desflurane anesthesia is suitable for neurosurgery.

Key words: neurosurgery, desflurane, BIS, SEF

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