首都医科大学学报 ›› 2003, Vol. 24 ›› Issue (4): 369-373.

• 论著·临床研究 • 上一篇    下一篇

重症SARS患者临床特点分析

赵虹, 魏嘉平, 李耘, 贾强, 姚小苓, 尹春林, 许立庆, 何冀芳, 吴晓光   

  1. 首都医科大学宣武医院
  • 收稿日期:2003-07-23 修回日期:1900-01-01 出版日期:2003-10-15 发布日期:2003-10-15

Clinical Features in SARS Patients in Severe Conditions

Zhao Hong, Wei Jiaping, Li Yun, Jia Qiang, Yao Xiaoling, Yin Chunlin, Xu Liqing, He Jifan, Wu Xiaoguang   

  1. Xuanwu Hospital, Capital University of Medical Sciences
  • Received:2003-07-23 Revised:1900-01-01 Online:2003-10-15 Published:2003-10-15

摘要: 为观察和分析重症严重急性呼吸综合征(severe acute respiratory syndrome,SARS)患者的临床特点及其影响因素,对我院收治的149例重症SARS患者进行回顾性分析,分别观察患者的一般情况、临床表现、化验指标、肺部阴影、心电图变化、各种治疗情况及预后。结果149例重症SRAS患者中男女比例相当,年龄多于25~75岁之间,40.3%合并慢性基础病,96.0%患者发热,58.0%外周血白细胞正常或降低,78.7%淋巴细胞减少,60%以上血生化多种酶升高,46.9%白蛋白/球蛋白(A/G)比值降低,37.6%血糖(GLU)升高,53.1%患者有低氧血症,81.8%肺损伤面积大,31.7%有心电图异常,58.7%有并发症。主要治疗包括糖皮质激素、抗生素、抗真菌药、抗病毒药、免疫增强剂、中药、吸氧和呼吸机辅助呼吸及支持疗法。最终痊愈和好转患者130人(占87.2%),死亡19人(12.8%)。提示高龄、合并基础疾病和并发症、肺损伤面积大、低氧血症严重、血生化改变大的患者病情重、病死率高。

关键词: SARS, 重症, 临床特点

Abstract: The objective was to observe and analyze the clinical features and related factors in SARS(severe acute respiratory syndrome)patients in severe condition.Methods:Clinical data of 149 patients with probable SARS in severe condition admitted in Xuanwu Hospital were analyzed retrospectively,including general appearance,clinical manifestations,laboratory findings,radiological findings,ECG,treatment and outcome respectively.Result:In 149 SARS patients in severe condition aged from 25to 75,the following were symploms:accompanied chronic diseases(40.3%),fever(96.0%),normal or decreased blood white cell count(58.0%),lymphopenia(78.7%),increased serum enzymes(60%),decreased albumin/globulin ratio(46.9%),increased glucose(37.6%),hypooxygenemia(53.1%),larger lung tissue damage site(81.8%),ECG abnormality(31.7%),complications(58.7%).Treatment included corticosteriods,antifungals,antibacterials and antivirals,immunopotentiator,traditional Chinese medicine,oxygen supply and mechanically supported respiration.The final recovery(87.2%)and mortality(12.8%)were found in these patients.Conclusion:Senility,underlying diseases,complications and larger lung tissue damag,severe abnormality in serum enzyme examination contribute to severe condition and higher mortality in SARS patient.

Key words: SARS, severe condition, clinical features

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