心血管病患者阿司匹林抵抗的临床特征

首都医科大学学报 ›› 2005, Vol. 26 ›› Issue (2): 128-131.

心血管病患者阿司匹林抵抗的临床特征

朱正炎, 胡大一, 史旭波, 王春波, 朱晶岩, 杨进刚, 李田昌

1. 首都医科大学附属北京同仁医院心血管疾病诊疗中心;2. 首都医科大学心脏病学系

收稿日期:2005-03-04 修回日期:1900-01-01 出版日期:2005-04-24 发布日期:2005-04-24

Clinical Characteristics of Aspirin Resistance in Patients with Cardiovascular Diseases

Zhu Zhengyan, Hu Dayi, Shi Xubo, Wang Chunbo, Zhu Jingyan, Yang Jingang, Li Tianchang

1. Department of Center of Cardiovascular Disease, Beijing Tongren Hospital, Capital University of Medical Sciences;2. Department of Cardiology, Capital University of Medical Sciences

Received:2005-03-04 Revised:1900-01-01 Online:2005-04-24 Published:2005-04-24

摘要/Abstract

摘要：

目的探讨心血管病患者阿司匹林抵抗(AR)的临床特征。方法对326例病情稳定的心血管病患者,采用血小板聚集仪分别测定花生四烯酸(AA)、二磷酸腺苷(ADP)诱导的血小板聚集率。阿司匹林抵抗即用0.5mmol/L花生四烯酸使血小板平均聚集率≥20%,用10μmol/L二磷酸腺苷使血小板平均聚集率≥70%。阿司匹林半抵抗(ASR)即符合阿司匹林抵抗条件之一者。结果阿司匹林抵抗发生率为4.9%(16/326),半抵抗发生率为27.6%(90/326)。与阿司匹林敏感(AS)者相比,AR的临床特征有:1)老年患者居多;2)女性患者居多;3)糖尿病患者居多;4)与高血压、高脂血症、红细胞计数、血红蛋白、血小板计数无关;5)较少见于吸烟者。结论阿司匹林抵抗发生率和国外报道相似,除老年、女性患者外,糖尿病也是阿司匹林抵抗的一个危险因素。

关键词: 心血管疾病, 阿司匹林, 抵抗

Abstract:

Objective The study was designed to investigate the clinical characteristics of aspirin resistance in patients with cardiovascular diseases.Methods 326 patients with stable cardiovascular diseases were evaluated for aspirin resistance with idetection of optical platelet aggregation induced by arachidonic acid(AA) and adenosine diphosphate(ADP). Aspirin resistance was defined as an average aggregation of over 20% with 0.5 mmol/L AAand over 70% with 10 μmol/L ADP. Aspirin semiresistance met one, but not both of the above criteria. Results 4.9% of the patients were aspirin resistant and 27.6% were aspirin-semiresistant. The clinical characteristics of aspirin resistant patients compared with aspirin sensitive patients were: 1) most of the aspirin-resistant patients were senile; 2) female patients were more frequent than male; 3) patients with diabetes were dominant in number; 4) it had nothing to do with hypertension, hyperlipodemia, red blood cell count, hemoglobin and platelet count; 5) it was relatively rare in smoking population. Conclusion The incidence of aspirin resistance is similar to other studies, in addition to aging and female gender, diabetes is also a risk factor in aspirin resistance.

Key words: cardiovascular diseases, aspirin, resistance

中图分类号:

R541

朱正炎;胡大一;史旭波;王春波;朱晶岩;杨进刚;李田昌. 心血管病患者阿司匹林抵抗的临床特征[J]. 首都医科大学学报, 2005, 26(2): 128-131.

Zhu Zhengyan;Hu Dayi;Shi Xubo;Wang Chunbo;Zhu Jingyan;Yang Jingang;Li Tianchang . Clinical Characteristics of Aspirin Resistance in Patients with Cardiovascular Diseases[J]. Journal of Capital Medical University, 2005, 26(2): 128-131.

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