关键词: 口腔干预, 医院内获得性肺炎, 复方氯己定, 0.9%氯化钠注射液

Abstract:

Objective To investigate the effects of different oral interventions to the incidence of the oropharyngeal respiratory aerobic pathogenic bacterial colonization and the morbidity of hospital-acquired pneumonia(HAP) in the long-term hospitalized elderly people. Methods Totally 62 elderly patients(>65 years) seen in our hospital were randomly divided into the treatment group(n=31) swab, supragingival plaque of every subjects at the first day(before intervention) and 30th day(after intervention) after enrolled. The incidence of the oropharyngeal respiratory aerobic pathogenic bacterial colonization and the morbidity of HAP between the two groups were compared. Results 1 The incidence of the pharyngeal respiratory aerobic pathogenic bacterial colonization after oral intervention(32.26%) was lower than before (58.06%) in the treatment group. And the incidence of the supragingival plaque colonization after oral intervention(27.59%) was lower than that obtained before(55.17%). The differences were all statistically significant(P<0.05). 2 The incidence of the pharyngeal respiratory aerobic pathogenic bacterial colonization after oral intervention(32.26%) was lower than that(54.84%) in the control group. The incidence of the supragingival plaque colonization after oral intervention(28.57%) was also lower than the previous one(53.57%). The differences were all statistically significant(P<0.05). 3 The morbidity of HAP of the treatment group and the control group were 10.20/1 000 hospitalizations and 14.12/1 000 hospitalizations, respectively. The difference was statistically significant(P<0.05). Conclusion The oral intervention of using compound chlorhexidine gargle or sterile saline daily both decreased the incidence of the oropharyngeal respiratory aerobic pathogenic bacterial colonization. But rinsing the mouth using compound chlorhexidine gargle for a long term could decrease the morbidity of HAP as compared with sterile saline.

Key words: oral intervention, hospital-acquired pneumonia, compound chlorhexidine gargle, sterile saline