首都医科大学学报 ›› 2013, Vol. 34 ›› Issue (4): 587-591.doi: 10.3969/j.issn.1006-7795.2013.04.021

• 临床研究 • 上一篇    下一篇

温肺化瘀定喘法治疗风寒袭肺型小儿病毒性毛细支气管炎的临床研究

刘晓红1, 林海2   

  1. 1. 首都医科大学附属北京友谊医院儿科, 北京 100050;
    2. 首都医科大学附属北京友谊医院中医科, 北京 100050
  • 收稿日期:2013-02-19 出版日期:2013-08-21 发布日期:2013-07-20
  • 通讯作者: 刘晓红 E-mail:lxhong50@sina.com
  • 基金资助:

    北京市中医药科技基金项目(JJ2011-12)。

Clinic study of using Chinese traditional method of lung warming, stasis transforming and panting stabilizing to cure wind-cold attacking lung type viral bronchiolitis in children

LIU Xiaohong1, LIN Hai2   

  1. 1. Department of Pediatrics, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China;
    2. Department of Chinese Traditional Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
  • Received:2013-02-19 Online:2013-08-21 Published:2013-07-20
  • Supported by:

    This study was supported by Beijing Traditional Chinese Medicine Science and Technology Fund(JJ2011-12).

摘要:

目的 本研究总结了2011年以来首都医科大学附属北京友谊医院儿科住院风寒袭肺型病毒性毛细支气管炎的中西结合治疗效果。旨在寻找更合理治疗小儿病毒性毛细支气管炎的中西医结合的方法。方法 风寒袭肺性病毒性肺炎、毛细支气管炎患者采用数字表法随机分为试验组28例和对照组22例,均给予基础治疗即沐舒坦静脉点滴、布地奈德、复方异丙托溴铵空气压缩泵雾化吸入,试验组口服温肺化瘀定喘汤(生麻黄、杏仁、细辛、桃仁、红花、桂枝、五味子等);对照组利巴韦林静脉注射、盐酸丙卡特罗口服。结果 气促消退时间、咳嗽减轻时间、住院天数明显减少,腹泻持续时间试验组短于对照组,差异有统计学意义(P<0.05)。2组的发热消退、气促减轻、咳嗽消退时间和湿啰音、啸鸣音、痰鸣音减少和消失时间比较,差异无统计学意义(P>0.05)。共检出呼吸道合胞病毒(respiratory syncytial virus,RSV)感染33例,流感病毒4例,腺病毒4例,副流感病毒5例,RSV感染占病毒毛细支气管炎的大多数。结论 李贵教授的温肺化瘀定喘方与西药组随机对照治疗风寒袭肺型小儿病毒性毛细支气管炎患儿,未发现试验组明显的不良反应,该方有一定的平喘、镇咳、化痰、降温等作用,尤其在缓解阵咳、喘憋等方面优于对照组。本研究中多为呼吸道合胞病毒(RSV)感染(33/50),少数为其他病毒感染,RSV感染仍有较高的发病率。

关键词: 中医, 中药, 温肺化瘀定喘法, 风寒袭肺型毛细支气管炎, 小儿

Abstract:

Objective This article summarizes the treatment effect of the inpatients suffering from wind-cold attacking lung type viral bronchiolitis in Department of Pediatrics, Beijing Friendship Hospital since 2010, using the method of integration of traditional and western medicine. It aimed at finding a more reasonable method of integration of traditional and western medicine to treat children with viral bronchiolitis.Methods We set up a parallel randomized controlled clinical study, dividing patients suffering from viral pneumonia and viral bronchiolitis of wind-cold attacking lung type into experimental group(28 cases) and control group(22 cases) randomly. All patients were treated with mucosolvan(ambroxol HCl) i.v., budesonide and compound Ipratropium bromide solution aerosol inhalation as basic treatment. The patients in experimental group were extra treated with lung-warming, stasis-transforming and panting-stabilizing decoction(consists of raw ephedra, apricot kernel, asarum, peach kernel, carthamus, cassia twig, shizandra berry, etc) p.o., while the patients of the control group were treated with ribavirin i.v. and procaterol HCl p.o..Results The time of anhelation subsiding, cough reducing and hospitalization of the patients in the experimental group was significantly reduced. And the duration of diarrhea of the patients in the experimental group was shorter than that of the patients in the control group, and the difference is significant(P<0.05). The time of fever abating, cough reducing, anhelation easing of the patients in the experimental group was not significantly different from that of the patients in the control group. And the time of the reduction and regression of moist rale, wheezing rale and phlegm rale of the patients in both groups was also not significantly different(P>0.05). 33 patients were detected of RSV infection, 4 were of influenza virus infection, 4 were of adenovirus infection and 5 were of parainfluenza virus infection. Thus, the majority of the patients were infected by RSV.Conclusion Comparing the treatment effects of the patients treated with lung-warming, stasis-transforming and panting-stabilizing decoction of professor Li Gui with that of the patients treated with western medicine, we can see that there is no significant toxic and side effect presenting in the patients of the experimental group. This decoction shows some effects in panting stabilizing, cough reducing, phlegm transforming and heat abating, especially in relieving paroxysmal coughing and panting. The majority of the patients involving in this study were infected by RSV, while the minority was infected by other viruses. Respiratory syncytial virus infection is still of a comparatively high incidence rate.

Key words: traditional Chinese medical science, traditional Chinese medicine, method of lung warming stasis transforming and panting stabilizing, wind-cold attacking lung type bronchiolitis, children

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