首都医科大学学报 ›› 2023, Vol. 44 ›› Issue (4): 583-589.doi: 10.3969/j.issn.1006-7795.2023.04.013

• 精神疾病中西医结合治疗 • 上一篇    下一篇

基于聚类分析与贝叶斯网络的惊恐障碍中医证候规律探索

宋明康1,2,  徐天朝3*#,  贾竑晓1,2*#,  李冬冬3,  郑思思1,2,  尹冬青1,2,  李  雪1,2   

  1. 1.首都医科大学附属北京安定医院 国家精神心理疾病临床医学研究中心 精神疾病诊断与治疗北京市重点实验室,北京 100088;2. 首都医科大学人脑保护高精尖创新中心,北京 100069;3.中国人民解放军北部战区总医院精神心理科,沈阳 110021
  • 收稿日期:2023-04-02 出版日期:2023-08-21 发布日期:2023-07-26
  • 通讯作者: 徐天朝,贾竑晓 E-mail:xtc_bucmp@126.com, jhxlj@ccmu.edu.cn
  • 基金资助:
    北京市医院管理中心“登峰”人才培养计划项目(DFL20191901),北京市医院管理中心临床医学发展专项(ZYLX202129),辽宁省自然科学基金项目(20170540961)

Exploration of traditional Chinese medicine syndrome discipline of panic disorder based on Cluster analysis and Bayesian network

Song Mingkang1,2, Xu Tianchao3*#, Jia Hongxiao1,2*#, Li Dongdong3, Zheng Sisi1,2, Yin Dongqing1,2, Li Xue1,2   

  1. 1. The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China; 2. Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100069, China;3.Department of Psychiatry, General Hospital of the Northern Theater of the Chinese People's Liberation Army, Shenyang 110021,China
  • Received:2023-04-02 Online:2023-08-21 Published:2023-07-26
  • Supported by:
    This study was supported by Beijing Hospitals Authoritys Ascent Plan (DFL20191901), Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support (ZYLX202129), Natural Science Foundation of  Liaoning Province (20170540961).

摘要: 目的  探索惊恐障碍的中医证候规律。方法  使用标准化的中医证候调查表采集193例符合惊恐障碍诊断标准的患者的四诊信息,并进行频率分析、聚类分析、贝叶斯网络分析,结合文献资料、专家意见判定证型分布。结果  193例惊恐障碍患者的中医证型主要包括心脾两虚(33.68%)、心肾不交(26.94%)、心胆气虚(16.06%)、脾肾两虚(12.95%)、脾胃湿热(10.36%)。结论  除脾胃湿热外,虚性证型在惊恐障碍中较为突出,包含心肾不交、心脾两虚、脾肾两虚、心胆气虚四类;且证型大多与“心”关联,涉及心肾不交、心脾两虚、心胆气虚三证。

关键词: 惊恐障碍, 中医证候, 聚类分析, 贝叶斯网络

Abstract: Objective  To explore the traditional Chinese medical (TCM) syndrome discipline of panic disorder. Methods  A standardized TCM syndrome inventory was used to collect symptoms based on the four diagnostic methods from 193 patients who met the criteria for panic disorder. Frequency analysis, Cluster analysis, and Bayesian network were performed, and relevant literatures and expert opinions were incorporated to determine the distribution of syndrome types. Results  The syndrome types of 193 patients with panic disorder involve the syndrome of deficiency of both heart and spleen (33.68%), syndrome of disharmony between heart and kidney (26.94%), syndrome of qi deficiency of heart and gallbladder (16.06%), syndrome of spleen-kidney deficiency (12.95%), syndrome of dampness-heat of spleen and stomach (10.36%). Conclusions  In addition to the syndrome of dampness-heat of spleen and stomach, syndrome types of deficiency seem to be more prominent in panic disorder, comprising syndrome of disharmony between heart and kidney, syndrome of deficiency of both heart and spleen, syndrome of spleen-kidney deficiency, syndrome of qi deficiency of heart and gallbladder. Also, most of the syndrome types are heart-related, involving syndrome of disharmony between heart and kidney, syndrome of deficiency of both heart and spleen, syndrome of qi deficiency of heart and gallbladder.

Key words: panic disorder, TCM syndrome discipline, Cluster analysis, Bayesian network

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