度洛西汀治疗人格解体-现实解体障碍的探索性研究

doi:10.3969/j.issn.1006-7795.2023.04.012

首都医科大学学报 ›› 2023, Vol. 44 ›› Issue (4): 578-582.doi: 10.3969/j.issn.1006-7795.2023.04.012

• 精神疾病中西医结合治疗 • 上一篇下一篇

度洛西汀治疗人格解体-现实解体障碍的探索性研究

郑思思^1,2，宋明康^1,2，宋楠^1,2，朱虹^1,2，贾竑晓^1,2*

1.首都医科大学附属北京安定医院国家精神心理疾病临床医学研究中心精神疾病诊断与治疗北京市重点实验室，北京 100088；2. 首都医科大学人脑保护高精尖创新中心，北京 100069

收稿日期:2023-04-02 出版日期:2023-08-21 发布日期:2023-07-26
通讯作者: 贾竑晓 E-mail:jhxlj@ccmu.edu.cn
基金资助:
北京市医院管理中心临床医学发展专项( ZYLX202129)，北京市医院管理中心青年人才培养“青苗”计划项目(QML20191901)，北京市医院管理中心“登峰”人才培养计划项目(DFL20191901)

A preliminary study on the therapeutic efficacy of Duloxetine in the treatment of depersonalization-derealization disorder

Zheng Sisi^1,2, Song Mingkang^1,2, Song Nan^1,2, Zhu Hong^1,2, Jia Hongxiao^1,2*

1．The National Clinical Research Center for Mental Disorders ＆ Beijing Key Laboratory of Mental Disorders，Beijing Anding Hospital， Capital Medical University，Beijing 100088，China; 2．Advanced Innovation Center for Human Brain Protection，Capital Medical University，Beijing 100069，China

Received:2023-04-02 Online:2023-08-21 Published:2023-07-26
Supported by:
This study was supported by the Beijing Hospitals Authority Clinical Medicine Development of Special Funding ( ZYLX202129), Beijing Hospitals Authority Youth Program (QML20191901)， and Beijing Hospitals Authority’s Ascent Plan (DFL20191901).

摘要/Abstract

摘要： 目的探索度洛西汀治疗人格解体-现实解体障碍（depersonalization-derealization disorder, DPD）的效果及影响因素。方法收集2020年1月至2022年12月就诊于首都医科大学附属北京安定医院度洛西汀治疗DPD的患者资料，采用生存分析方法进行疗效及影响因素分析。结果本研究共纳入51名患者，64.7%的患者治疗有效，中位有效时间为118（87, 643）d，且对情感麻木症状具有改善较快的趋势。受教育年限为度洛西汀治疗的影响因素HR=0.81(0.70,0.95)，P=0.008。结论度洛西汀治疗DPD，尤其是以情感麻木为主诉的患者具有潜在获益，可为临床治疗DPD提供指导。

关键词: 度洛西汀, 人格解体-现实解体障碍, 疗效分析

Abstract: Objective To explore the efficacy and influencing factors of Duloxetine in the treatment of depersonalization-derealization disorder (DPD). Methods The data were collected from January 2020 to December 2022 for DPD patients treated with Duloxetine at Beijing Anding Hospital, Capital Medical University. Survival analysis was used to analyze treatment efficacy and influencing factors. Results A total of 51 patients were included in this study, and 64.7% of the patients showed treatment efficacy. The median effective time was 118 (87, 643) days, and there was a trend of rapid improvement in emotional numbness symptoms. Education level was identified as a significant influencing factor for duloxetine treatment, with HR=0.81 (0.70, 0.95), P=0.008. Conclusions Duloxetine treatment for DPD, particularly for the patients with emotional numbness as the main complaint, has potential benefits and provides guidance for clinical treatment of DPD.

Key words: Duloxetine, depersonalization-derealization disorder, therapeutic efficacy

中图分类号:

郑思思, 宋明康, 宋楠, 朱虹, 贾竑晓. 度洛西汀治疗人格解体-现实解体障碍的探索性研究[J]. 首都医科大学学报, 2023, 44(4): 578-582.

Zheng Sisi, Song Mingkang, Song Nan, Zhu Hong, Jia Hongxiao. A preliminary study on the therapeutic efficacy of Duloxetine in the treatment of depersonalization-derealization disorder[J]. Journal of Capital Medical University, 2023, 44(4): 578-582.

参考文献

［1］ Yang J Y, Millman L S M, David A S, et al. The prevalence of depersonalization-derealization disorder: a systematic review［J］. J Trauma Dissociation, 2023, 24(1): 8-41.
［2］ Michal M, Adler J, Wiltink J, et al. A case series of 223 patients with depersonalization-derealization syndrome［J］. BMC Psychiatry, 2016, 16: 203.
［3］ Simeon D, Knutelska M, Putnam F W, et al. Attention and memory in depersonalization-spectrum dissociative disorders: impact of selective-divided attentional condition, stimulus emotionality, and stress［J］. J Trauma Dissociation, 2023, 24(1): 42-62.
［4］徐蕊, 杨敬铭, 朱虹, 等. 人格解体障碍病人的自我面孔识别速度的研究［J］. 首都医科大学学报, 2017, 38(2): 192-196.
［5］贾竑晓, 徐蕊, 朱虹, 等. 人格解体障碍的自我认知损害的神经心理学研究进展［J］. 国际精神病学杂志, 2016, 43(1): 50-54.
［6］宋楠, 贾竑晓. 人格解体患者认知功能及与临床症状和社会功能的相关性［J］. 首都医科大学学报, 2020, 41(1): 59-63.
［7］ Hunter E C M, Charlton J, David A S. Depersonalisation and derealisation: assessment and management［J］. BMJ, 2017, 356: j745.
［8］ Sierra M. Depersonalization disorder: pharmacological approaches［J］. Expert Rev Neurother, 2008, 8(1): 19-26.
［9］ Simeon D, Guralnik O, Knutelska M, et al. Basal norepinephrine in depersonalization disorder［J］. Psychiatry Res, 2003, 121(1): 93-97.
［10］ American Psychiatric Association, American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-5［M］. 5th ed. Washington, D.C.: American Psychiatric Association, 2013:302.
［11］ Jay E L, Sierra M, Van Den Eynde F, et al. Testing a neurobiological model of depersonalization disorder using repetitive transcranial magnetic stimulation［J］. Brain Stimul, 2014, 7(2): 252-259.
［12］ Simeon D, Kozin D S, Segal K, et al. De-constructing depersonalization: further evidence for symptom clusters［J］. Psychiatry Res, 2008, 157(1/3): 303-306.
［13］ Segal S K, Cahill L. Endogenous noradrenergic activation and memory for emotional material in men and women［J］. Psychoneuroendocrinology, 2009, 34(9): 1263-1271.
［14］ Montagrin A, Sander D. Emotional memory: from affective relevance to arousal［J］. Behav Brain Sci, 2016, 39: e216.
［15］ Segal S K, Stark S M, Kattan D, et al. Norepinephrine-mediated emotional arousal facilitates subsequent pattern separation［J］. Neurobiol Learn Mem, 2012, 97(4): 465-469.

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度洛西汀治疗人格解体-现实解体障碍的探索性研究

A preliminary study on the therapeutic efficacy of Duloxetine in the treatment of depersonalization-derealization disorder

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