稳定期慢性阻塞性肺疾病患者康复治疗氧化应激的随访研究

doi:10.3969/j.issn.1006-7795.2013.04.027

摘要/Abstract

摘要：

目的探讨运动康复对稳定期慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者氧化应激的影响。方法选择经肺功能测定属于GOLD Ⅱ~Ⅲ级的确诊患者15例,接受48周强化及非强化运动训练。在试验前、第一次强化训练后及完成48周运动训练后测定患者相关氧化应激反应指标。对所得结果用SPSS 17.0统计学软件进行分析,以P<0.05为差异有统计学意义。结果 ① 15例COPD患者全部完成48周运动康复训练;② COPD患者经过48周系统运动训练后与运动前比较,血浆丙二醛(malondialdehyde,MDA)浓度降低,超氧化物歧化酶 (superoxide dismutase,SOD)升高,差异有统计学意义(P<0.05);COPD患者首次强化运动后与运动前比较,血清MDA及SOD差异无统计学意义(P>0.05)。结论 ① 系统运动训练有助于改善COPD患者的氧化-抗氧化失衡水平;② 单次强化运动训练对稳定期中重度COPD患者全身氧化应激水平无显著影响。

关键词: 慢性阻塞性肺疾病, 肺康复, 氧化应激

Abstract:

Objective To investigate the effects of pulmonary rehabilitation on oxidative stress in patients with stable chronic obstructive pulmonary disease(COPD). Methods Fifteen(10 males, 5 females) stable COPD patients, mean(SD) age 55.73(9.75) years, body mass index(BMI) 21 kg/m² to 32 kg/m²〔an average of (25.60±2.99)kg/m²〕, forced expiatory volume in one second(FEV1)/predicted more than 30%, were enrolled into this 48 weeks of rehabilitation program. The response of cytokine were measured at pre-, post- and first post-maximal exercise training. The response of oxidative stress was measured from serum level of malondialdehyde(MDA) and superoxide dismutase(SOD). A p-value of less than 0.05 was considered significant for the results of all stratified analyses. Results Fifteen patients completed the study. There was no significant change in level of MDA and SOD between pre- and first post-maximal exercise training(P>0.05). The cytokine level of serum MDA was markedly decreased after 48 weeks exercise training, compared to that before training(P<0.05). The level of serum SOD was significantly increased after 48 weeks training, compared to that before training(P<0.05). Conclusion The level of oxidative stress was significantly improved by 48 weeks exercise training. There was no significant response of oxidative stress associated with maximal exercise before or after training in COPD patients.

Key words: chronic obstructive pulmonary disease(COPD), pulmonary rehabilitation(PR), oxidative stress

中图分类号:

R563.3

周文波, 聂秀红. 稳定期慢性阻塞性肺疾病患者康复治疗氧化应激的随访研究[J]. 首都医科大学学报, 2013, 34(4): 615-618.

ZHOU Wenbo, NIE Xiuhong. Follow-up study on rehabilitation therapy of oxidative stress in patients with stable chronic obstructive pulmonary disease[J]. Journal of Capital Medical University, 2013, 34(4): 615-618.

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