蜕膜自然杀伤细胞在人早孕期基蜕膜和壁蜕膜的分布比较

首都医科大学学报 ›› 2011, Vol. 32 ›› Issue (2): 259-262.

蜕膜自然杀伤细胞在人早孕期基蜕膜和壁蜕膜的分布比较

王伟¹，王景²，翁静^2*

1. 首都医科大学燕京医学院组织学与胚胎学教研室； 2. 首都医科大学基础医学院组织学与胚胎学教研室

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-04-21 发布日期:2011-04-21
通讯作者: 翁静

Comparison of the Number of Decidual Natural Killer Cells between Decidua Basalis and Decidua Parietalis in Human First Trimester

WANG Wei¹, WANG Jing², WENG Jing^2*

1. Department of Histology and Embryology, Yanjing Medical College, Capital Medical University; 2. Department of Histologyand Embryology, School of Basic Medical Sciences, Capital Medical University

Received:1900-01-01 Revised:1900-01-01 Online:2011-04-21 Published:2011-04-21
Contact: WENG Jing

摘要/Abstract

摘要：

目的对比蜕膜自然杀伤(decidual natural killer，dNK)细胞在人早孕期同一个体基蜕膜和壁蜕膜中的分布，探讨其在早孕期的可能作用。
方法采用HE染色和免疫组织化学方法标记细胞角蛋白7阳性细胞以区分壁蜕膜和基蜕膜，进而检测CD56的表达，从而显示壁蜕膜和基蜕膜中dNK细胞的数量。
结果基质中有细胞角蛋白7阳性的绒毛外滋养层细胞的是基蜕膜标记；CD56呈阳性反应的dNK细胞在基蜕膜中的数量明显多于（P<0.01）壁蜕膜。
结论蜕膜自然杀伤细胞在人正常早孕蜕膜中的分布不同，其可能与滋养层细胞的侵入有关。

关键词: 蜕膜自然杀伤细胞, 基蜕膜, 壁蜕膜

Abstract:

Objective To investigate the human decidual natural killer(dNK) cells in decidua basalis(DB) and decidua parietalis(DP) during early pregnancy and its possible functions.
Methods DB and DP of the same early pregnant individual were discriminated by HE staining and expression of Keratin 7 by immunohistochemistry. The CD56⁺dNK cells were shown by immunohistochemistry. The number of dNK cells in DB or DP was counted.
Results Cytokeratin 7-positive extravillous trophoblast cells was a marker to distinguish DB and DP because they only present in DB. The number of CD56⁺ dNK cells in DB was significantly larger than that in DP(P<0.01).
Conclusion The differential distribution of dNK cells in early pregnant decidua may be related to trophoblast invasion.

Key words: decidual natural killer cells, decidua basalis, decidua parietalis

中图分类号:

R 711

王伟;王景;翁静. 蜕膜自然杀伤细胞在人早孕期基蜕膜和壁蜕膜的分布比较[J]. 首都医科大学学报, 2011, 32(2): 259-262.

WANG Wei;WANG Jing;WENG Jing. Comparison of the Number of Decidual Natural Killer Cells between Decidua Basalis and Decidua Parietalis in Human First Trimester[J]. Journal of Capital Medical University, 2011, 32(2): 259-262.

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