Tosight喉镜用于新生儿气管插管时七氟醚吸入肺泡气浓度

doi:10.3969/j.issn.1006-7795.2015.03.026

首都医科大学学报 ›› 2015, Vol. 36 ›› Issue (3): 469-472.doi: 10.3969/j.issn.1006-7795.2015.03.026

Tosight喉镜用于新生儿气管插管时七氟醚吸入肺泡气浓度

陈丽丽, 张建敏, 郑铁华

首都医科大学附属北京儿童医院麻醉科, 北京 100045

收稿日期:2014-07-01 出版日期:2015-06-21 发布日期:2015-06-15
通讯作者: 张建敏 E-mail:zjm428@sina.com

A study on minimum alveolar concentration EI₅₀ and EI₉₅ sevoflurane during intubation with Tosight video larygoscope in neonates

Chen Lili, Zhang Jianmin, Zheng Tiehua

Department of Anesthesiology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China

Received:2014-07-01 Online:2015-06-21 Published:2015-06-15

摘要/Abstract

摘要：

目的测定新生儿Tosight喉镜气管插管时七氟醚吸入的半数肺泡气浓度(minimum alveolar concentrations effective inhaled concentrations in 50%, MAC EI₅₀)和95%有效肺泡气浓度(minimum alveolar concentrations effective inhaled concentrations in 95%, MAC EI₉₅).方法选择22例美国麻醉医师协会(American Society of Anesthesiologists,ASA)Ⅰ或Ⅱ级择期全身麻醉手术的新生儿,吸入七氟醚麻醉,初次浓度设置为3.3%,相邻浓度比为1.1,七氟醚的浓度按改良序贯法增加或减少一级,待七氟醚的浓度达血－脑平衡10 min后行气管插管.用概率单位回归法计算出新生儿Tosight喉镜气管插管时七氟醚吸入诱导的肺泡气浓度MAC EI₅₀ 和EI₉₅ 及相应的95% 可信区间(confidence interval,95%CI).结果全凭七氟醚吸入诱导Tosight喉镜气管插管时患儿肺泡气浓度的MAC EI₅₀为3.65%,95% CI 为3.28%~4.04%; MAC EI₉₅ 为4.24%,95% CI为3.93% ~7.14%.结论 Tosight喉镜用于新生儿气管插管时的肺泡气浓度的MAC EI₅₀ 和EI₉₅分别为3.65%和4.24%.

关键词: Tosight喉镜, 七氟醚, 新生儿, 改良序贯法

Abstract:

Objective To measure the minimum alveolar concentration (MAC EI₅₀ and EI₉₅) of sevoflurane during intubation with Tosight video larygoscope in neonates. Methods Twenty-two ASAⅠor Ⅱ infants under operations in general anesthesia were induced by sevoflurane. Initial concentration is set to 3.3%, the adjacent concentration ratio is 1.1.The concentration of sevoflurane was determined via the modified Dixon's up-and-down method (a level as a step size). After equilibrium between blood and brain concentration of sevoflurane, the trachea was intubated. Probit analysis was used for calculating MAC EI₅₀, EI₉₅ and 95% confidence interval (95%CI). Results The MAC EI₅₀ of sevoflurace was 3.65% (95%CI : 3.28%-4.04%) and EI₉₅ of sevoflurace was 4.24% (95%CI : 3.93%-7.14%). Conclusion The MAC EI₅₀ and EI₉₅ of sevoflurane during Tosight video laryngoscope intubation in neonates were 3.65% and 4.24%.

Key words: Tosight video laryngoscope, sevoflurance, neonates, the modified Dixon's up-and-down method

中图分类号:

R246.2

陈丽丽, 张建敏, 郑铁华. Tosight喉镜用于新生儿气管插管时七氟醚吸入肺泡气浓度[J]. 首都医科大学学报, 2015, 36(3): 469-472.

Chen Lili, Zhang Jianmin, Zheng Tiehua. A study on minimum alveolar concentration EI₅₀ and EI₉₅ sevoflurane during intubation with Tosight video larygoscope in neonates[J]. Journal of Capital Medical University, 2015, 36(3): 469-472.

参考文献

[1] Min S K, Kw ak Y L, Park S Y, et al. The optimal dose of remifentanil for intubation during sevoflurane induction without neuromuscular blockade in children[J]. Anaesthesia, 2007,62(5): 446-450.
[2] Viby-Mogensen J, Engbaek J, Erikss on L I, et al. Good clinical research practice (GCRP) in pharmacodynamic studies of neuromuscular blocking agents[J]. Acta Anaesthesiol Scand,1996, 40(1): 59-74.
[3] 林震岩. 多变量分析: SPSS 的操作与应用[M]. 北京: 北京大学出版社, 2007: 543-576.
[4] 王烨,王磊,邓晓明,等.Tosight视频喉镜用于患儿气管插管的临床研究[J].临床麻醉学志,2013,29(1):39-41.
[5] Vanderhal A L,Berci G, Simmons C F Jr, et al. A videolaryngoscopy technique for the intubation of the newborn : preliminary report[J]. Pediatrics,2009,124(2):339-346.
[6] Xue F S, Cheng Y, Wang Q. Tracheal intubation performed with glidescope? Video laryngoscope and direct laryngoscopy in neonates and infant[J]. Anesthesiology, 2012, 117(4):914-915.
[7] Park H J, Lee J R, Kim C S, et al. Remifentanil halves the EC50 of propofol f or successful insertion of the laryngeal mask air way and laryngeal tube in pediat ric patients[J]. Anesth Analg, 2007, 105(1): 57-61.
[8] Olofsen E, Dahan A. The dynamic relationship between endtidal sevoflurane and isoflurane concentrations and bispectral index and spectral edge f requency of the electroen cephalogram[J]. Anesthesiology, 1999, 90(5): 1345-1353.
[9] 胡璟,张建敏,王芳,等. 七氟醚诱导对患儿镇静和循环的影响[J].临床麻醉学杂志,2009,25(10):860-862.
[10] 马丽,刘永哲,马亚群,等. 新生儿七氟醚麻醉下无肌松剂行腹腔镜手术的临床观察[J]. 临床误诊误治,2013,26(12):56-58.
[11] 于威威,季海音,赵平. 咪达唑仑滴鼻对小儿七氟醚麻醉苏醒期躁动的预防作用[J]. 中国医科大学学报,2013,42(9):849-851.

[1]	张瑾, 池晶晶, 张蕊, 张小燕, 白文佩. 孕前肥胖及超重女性的孕期管理模式探讨及肥胖相关胎盘因子分析[J]. 首都医科大学学报, 2022, 43(5): 774-781.
[2]	杨亚利, 黄丽辉, 程晓华, 刘莎. 前庭导水管扩大患儿影像与听力结果分析[J]. 首都医科大学学报, 2022, 43(4): 535-539.
[3]	蔡晓飞, 牛少宁, 丁乔, 程灏. 不同麻醉药物行全身麻醉复合硬膜外阻滞对肝脏切除术后肝肾功能的影响[J]. 首都医科大学学报, 2017, 38(3): 352-356.
[4]	王晓娇, 王亚娟, 邵芳, 杨学芳, 何建平, 王慧欣, 顾松, 杨彩云, 钟雁, 林影, 刘颖. 新生儿黄疸换血疗法对新生儿内环境的影响[J]. 首都医科大学学报, 2016, 37(2): 136-140.
[5]	辛玥, 郑荣秀. 新生儿呼吸窘迫综合征合并气胸27例临床分析[J]. 首都医科大学学报, 2016, 37(2): 148-152.
[6]	王红梅, 代荫梅, 田玉翠, 薛智方. 子宫肌瘤对双胎胎儿生长发育及新生儿结局的影响[J]. 首都医科大学学报, 2015, 36(4): 573-577.
[7]	王艳, 李云娟, 王雷. 新生儿轮状病毒感染临床特点分析[J]. 首都医科大学学报, 2014, 35(4): 496-500.
[8]	于芸, 张凯颖, 韩如泉. 七氟醚与丙泊酚用于成人开颅手术麻醉的比较：系统评价与Meta分析[J]. 首都医科大学学报, 2013, 34(5): 733-741.
[9]	马秀华;宋风丽;马丽丽;石鑫;李妍;史伟;王春霞;刘盈;马琳. 母婴同室新生儿皮肤感染调查分析[J]. 首都医科大学学报, 2011, 32(4): 456-459.
[10]	袁秀珍;崔志清;郝兰香. 新生儿游泳对黄疸及情绪的影响[J]. 首都医科大学学报, 2009, 30(2): 249-251.
[11]	赵友萍;周琦;黄醒华. 第二产程胎心监护异常与新生儿预后的关系[J]. 首都医科大学学报, 2006, 27(3): 414-417.
[12]	何建平;申昆玲;林影;吴明昌;王咏红;杨学芳;王亚娟;邵芳. 前降钙素对新生儿重症感染的诊断价值[J]. 首都医科大学学报, 2005, 26(5): 545-548.
[13]	刘彤;王凤英;周齐;刘维靖;幺宏彦. 新生儿窒息与产科高危因素的临床分析[J]. 首都医科大学学报, 2005, 26(5): 624-626.
[14]	姜桂英;吴庆庆. 新生儿产伤性锁骨骨折141例分析[J]. 首都医科大学学报, 2002, 23(1): 68-69.
[15]	刘玉环;王瑛. 羊水过少202例临床分析[J]. 首都医科大学学报, 1999, 20(3): 205-207.

Tosight喉镜用于新生儿气管插管时七氟醚吸入肺泡气浓度

A study on minimum alveolar concentration EI₅₀ and EI₉₅ sevoflurane during intubation with Tosight video larygoscope in neonates

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

Tosight喉镜用于新生儿气管插管时七氟醚吸入肺泡气浓度

A study on minimum alveolar concentration EI50 and EI95 sevoflurane during intubation with Tosight video larygoscope in neonates

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

A study on minimum alveolar concentration EI₅₀ and EI₉₅ sevoflurane during intubation with Tosight video larygoscope in neonates