子宫肌瘤对双胎胎儿生长发育及新生儿结局的影响

doi:10.3969/j.issn.1006-7795.2015.04.011

首都医科大学学报 ›› 2015, Vol. 36 ›› Issue (4): 573-577.doi: 10.3969/j.issn.1006-7795.2015.04.011

• 更年期与妇科生殖内分泌 • 上一篇下一篇

子宫肌瘤对双胎胎儿生长发育及新生儿结局的影响

王红梅, 代荫梅, 田玉翠, 薛智方

首都医科大学附属北京妇产医院妇科, 北京 100026

收稿日期:2015-05-22 出版日期:2015-08-21 发布日期:2015-07-17
通讯作者: 代荫梅 E-mail:fcyydym@163.com
基金资助:
北京市科技计划项目(Z131107002213090),北京市医院管理局临床医学发展专项(ZYLX201510)。

Effect of uterine fibroids on fetal growths and neonatal outcomes in twin pregnancies

Wang Hongmei, Dai Yinmei, Tian Yucui, Xue Zhifang

Department of Gynecology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China

Received:2015-05-22 Online:2015-08-21 Published:2015-07-17
Supported by:
This study was supported by the Beijing Municipal Science&Technology Commission(Z131107002213090), Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support(ZYLX201510).

摘要/Abstract

摘要：

目的前瞻性评估子宫肌瘤对双胎胎儿生长发育及新生儿结局的影响。方法选取在首都医科大学附属北京妇产医院建档并于2013年6月至2014年12月分娩的双胎妊娠合并子宫肌瘤患者共46例作为研究组,以及双胎妊娠无肌瘤者63例作为对照组,观察并记录其孕早期、中期、晚期B超监测胎儿生长发育指标、新生儿出生情况及妊娠结局。结果与对照组相比,双胎妊娠合并子宫肌瘤患者的年龄〔(35.04±4.24)岁vs(31.67±3.56)岁,P=0.000〕和孕前体质量指数〔(21.46±3.69)kg/m² vs(20.77±2.38)kg/m²,P=0.009〕明显增加,且在11~14周B超的羊水最大暗区垂直深度明显降低〔(3.14±0.55)cm vs(3.38±0.55)cm,P=0.001)〕,差异具有统计学意义。然而,其他孕早、中、晚期的生长发育指标、新生儿出生情况及妊娠结局差异均无统计学意义。结论子宫肌瘤对双胎胎儿生长发育及新生儿结局的影响并不明显。但考虑到双胎妊娠本身是妊娠的一项高危因素,对双胎妊娠合并子宫肌瘤患者,更应加强对其进行密切的监护和管理,从而使母、儿得到更合理、更安全的治疗。

关键词: 子宫肌瘤, 双胎, 生长发育, 新生儿

Abstract:

Objective To prospectively estimate the effect of fibroids on fetal growths and neonatal outcomes in twin pregnancies. Methods Data of 46 twin pregnancies with fibroids delivered from June 2013 to December 2014 in Beijing Obstetrics and Gynecology Hospital, Capital Medical University who have already established their records were collected. And data were also collected from 63 twin pregnancies without fibroids as matched group. The monitoring parameters of ultrasounds in their early, middle and late pregnancy and neonatal conditions and obstetric outcomes were observed and recorded. Results Twin pregnancies with fibroids were more likely to be of advanced maternal age 〔(35.04±4.24)years vs (31.67±3.56)years, P=0.000〕, higher pre-pregnancy body mass index 〔(21.46±3.69)kg/m² vs (20.77±2.38)kg/m², P=0.009〕 and had lower amniotic fluid volume〔(3.14±0.55)cm vs (3.38±0.55)cm, P=0.001〕 in 11-14 weeks ultrasound compared with twin pregnancies without fibroids. However, other parameters of fetal growths in early, middle and late pregnancy, neonatal conditions and obstetric outcomes had no statistical significance between twin pregnancies with fibroids and those without fibroids. Conclusion Fibroids' effect on fetal growths and neonatal outcomes in twin pregnancies is not obvious. But twin pregnancy is a high risk factor for pregnancy and we should give more monitoring and management for twin pregnancy with fibroids, so that mothers and newborns get more reasonable and secure treatment.

Key words: fibroids, twin pregnancy, growth, newborns

中图分类号:

R711.74

王红梅, 代荫梅, 田玉翠, 薛智方. 子宫肌瘤对双胎胎儿生长发育及新生儿结局的影响[J]. 首都医科大学学报, 2015, 36(4): 573-577.

Wang Hongmei, Dai Yinmei, Tian Yucui, Xue Zhifang. Effect of uterine fibroids on fetal growths and neonatal outcomes in twin pregnancies[J]. Journal of Capital Medical University, 2015, 36(4): 573-577.

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子宫肌瘤对双胎胎儿生长发育及新生儿结局的影响

Effect of uterine fibroids on fetal growths and neonatal outcomes in twin pregnancies

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