人乳头瘤病毒基因分型检测在30岁以下年轻妇女宫颈病变中的应用价值

doi:10.3969/j.issn.1006-7795.2015.04.014

首都医科大学学报 ›› 2015, Vol. 36 ›› Issue (4): 588-591.doi: 10.3969/j.issn.1006-7795.2015.04.014

人乳头瘤病毒基因分型检测在30岁以下年轻妇女宫颈病变中的应用价值

吕虹^1,2, 康熙雄^1,2, 张国军^1,2

1. 首都医科大学附属北京天坛医院检验科, 北京 100050;
2. 北京市免疫试剂临床工程技术研究中心, 北京 100050

收稿日期:2015-06-01 出版日期:2015-08-21 发布日期:2015-07-17
通讯作者: 张国军 E-mail:tiantanzgj@163.com
基金资助:
北京市卫生系统高层次卫生技术人才培养项目(2013-3-052)。

Value of genotyping test for human papillomavirus(HPV) in women under 30 years of age with cervical lesions

Lyu Hong^1,2, Kang Xixiong^1,2, Zhang Guojun^1,2

1. Department of Central Laboratory, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China;
2. Beijing Engineering Research Center of Immunological Reagents Clinical Research, Beijing 100050, China

Received:2015-06-01 Online:2015-08-21 Published:2015-07-17
Supported by:
This study was supported by High Level Technical Talent Development of Beijing Health System(2013-3-052).

摘要/Abstract

摘要：

目的探讨人乳头瘤病毒(human papillomavirus,HPV)基因分型检测在30岁以下年轻妇女宫颈病变中的应用价值,为年轻妇女宫颈病变筛查提供依据。方法选取985例30岁以下年轻妇女,通过病理学或细胞学检测分为体检组、疣状病变组、宫颈炎性病变组、宫颈上皮内瘤样病变组及宫颈癌组,采用人乳头瘤病毒基因分型检测方法进行分析,其中包括13种高危型HPV(16、18、31、33、35、39、45、51、52、56、58、59、68),5种低危型HPV(6、11、42、43、44)和3种中国人常见的基因型HPV(53、66和CP8304)。结果 HPV总检出率为21.42%(211/985),其中高危型检出率为25.38%(250/985),低危型检出率为3.76%(37/985),多重感染占24.17%,宫颈上皮内瘤样病变与宫颈癌组同体检组相比较,差异有统计学有意义(P<0.05)。结论年轻妇女HPV-DNA检测非常重要,对发现宫颈癌及癌前病变很有价值。

关键词: 人乳头瘤病毒, 分型, 年轻妇女, 宫颈癌

Abstract:

Objective To explore the application value of genotyping test for human papillomavirus(HPV) in women under 30 years of age with cervical lesions, so as to provide evidences for cervical lesion screening in young women. Methods Totally of 985 young women under 30 years of age were assigned to physical examination group, verrucous lesion group, cervical inflammation group, cervical intraepithelial neoplasia(CIN) group and cervical carcinoma group by pathological or cytological test. An analysis was performed using genotyping test for human papillomavirus(HPV) , including 13 high-risk HPV types(16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68), 5 low-risk HPV types(6, 11, 42, 43 and 44) and 3 common HPV genotypes in Chinese(53, 66 and CP8304). Results The total detection rate of HPV was 21.42%(211/985). The detection rate was 25.38%(250/985) for high risk HPV, 3.76%(37/985) for low risk HPV and 24.17% for multiple infections. There was statistically significant difference between cervical intraepithelial neoplasia and cervical carcinoma groups with physical examination group. Conclusion HPV-DNA test is very important for young women and of great value on detecting cervical carcinoma and precancerous lesion.

Key words: human papillomavirus, genetype, young woman, cervical carcinoma

中图分类号:

R446.1

吕虹, 康熙雄, 张国军. 人乳头瘤病毒基因分型检测在30岁以下年轻妇女宫颈病变中的应用价值[J]. 首都医科大学学报, 2015, 36(4): 588-591.

Lyu Hong, Kang Xixiong, Zhang Guojun. Value of genotyping test for human papillomavirus(HPV) in women under 30 years of age with cervical lesions[J]. Journal of Capital Medical University, 2015, 36(4): 588-591.

参考文献

[1] Parkin D M, Bray F, Ferlay J, et al. Estimating the world cancer burden: Globocan[J]. Int J Cancer, 2001,94(2):153-156.
[2] Zhang W Y, Xue Y Z, Chen M, et al. Prevalence of high-risk human papillomavirus infection in different cervical lesion among organized health-examination women in Shanghai, Cnina[J]. Chin Med J, 2008,121(16):1578-1582.
[3] Costa S, Venturoli S, Negri G, et al. Factors predicting the outcome of conservatively treated adenocarcinoma in situ of the uterinecervix: an analysis of 166 cases[J]. Gynecol Oncol, 2012,124(3):490-495.
[4] Michelli E, Téllez L, Mendoza J A, et al. Comparative analysis of three methods for HPV DNA detection in cervical samples[J]. Invest Clin, 2011,52(4):344-357.
[5] Cai H B, Ding X H, Chen C C. Prevalence of single and multiple human papillomavirus types in cervical cancer and precursor lesions in hubei, China[J]. Oncology, 2009,76(3):157-161.
[6] 吕虹,刘志忠,刘竞争,等.人乳头瘤病毒基因分型检测在绝经妇女HPV感染中的应用价值[J].中国老年学杂志,2011,11(31):2117-2118.
[7] 胥莎莎,何鑫,刘英俏,等.高危型人乳头瘤病毒感染患者病毒清除剂持续感染的随访性研究[J].首都医科大学学报,2015,2:212-218.
[8] 柯吴坚,车雅敏,田敬群,等.性病门诊性传播疾病病原体混合感染情况调查[J].首都医科大学学报,2011,32(4):460-463.
[9] Gmvitt P E, Kovacic M B, Herrero R, et al. High load for most high risk human papillomavirus genotypes is associated with prevalent cervical cancer precursors but only HPV16 load predicts the development of incident disease[J]. Int J Cancer, 2007,121(12):2787-2793.
[10] Lillo F B, Lodini S, Ferrari D, et al. Determination of human papillomavirus(HPV) load and type in high-garde cervical lesions surgically resected from HIV-infected women during follow-up of HPV infection[J]. Clin Infect Dis, 2005,40(3):451-457.
[11] Baandrup L, Munk C, Andersen K K, et al. HPV16 is associated with younger age in women with cervical intraepithelial neoplasia grade 2 and 3[J]. Gynecol Oncol, 2012,124(2):281-285.
[12] Frega A, Lorenzon L, Giovagnoli M R, et al. Prognostic implication of high risk human papillomavirus E6 and E7 mRNA in patients with intraepithelial lesions of the cervix in relationship to age[J]. Int J Immunopathol Pharmacol, 2011,24(2):461-470.
[13] Roncaglia M T, Tacla M, Vieira da Motta E, et al. Evaluation of the combination of cytology and hybrid capture to safely predict the high-grade lesion status of patients treated with conization with large loop excision of the transformation zone[J]. Acta Cytol, 2011,55(5):421-425.
[14] 袁林,徐又先,陈静,等.高危型HPV感染者负性生活事件暴露与宫颈癌发生相关性分析[J].中华肿瘤防治杂志,2013,20(19):1465-1468.
[15] 常小垒,郭科军,张颐.HPV亚型与子宫颈癌前病变及癌变的关系探讨[J].中国医科大学学报,2014,43(8):72-723,727.
[16] 王平,牛丽满,王德华.年轻妇女宫颈癌的临床特征及预后因素的分析[J].中国煤炭工业医学杂志,2013,16(2):183-185.
[17] 黄宝英,周伦顺,富显果,等.HPV E6/E7 mRNA检测对宫颈癌筛查意义的初步评价[J].中华肿瘤防治杂志,2013,20(14):1061-1064.

人乳头瘤病毒基因分型检测在30岁以下年轻妇女宫颈病变中的应用价值

Value of genotyping test for human papillomavirus(HPV) in women under 30 years of age with cervical lesions

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