首都医科大学学报 ›› 2006, Vol. 27 ›› Issue (2): 271-274.

• 综述 • 上一篇    下一篇

与帕金森病相关的致病基因研究进展

彭继英, 孙异临   

  1. 首都医科大学北京市神经外科研究所
  • 收稿日期:2005-04-12 修回日期:1900-01-01 出版日期:2006-04-24 发布日期:2006-04-24

The Study in Pathogenic Gene Associate with Parkinsonis Disease

Peng Jiying, Sun Yilin   

  1. Beijing Neurosurgery Institute, Capital University of Medical Sciences
  • Received:2005-04-12 Revised:1900-01-01 Online:2006-04-24 Published:2006-04-24

Abstract: Parkinson disease is a kind of neurodegenerative disease.The classic pathological finding of Parkinson disease is Lewy body(LB).Certain genic mutation would induce Parkinson disease,such as α-synuclein,Parkin,UCHL1 which are ascertained to be associated to Parkinson disease.These gene mutants damage the ubiquitin-proteasomes system(UPS),the UPS dysfunction would lead to Parkinson disease.This review discasses the relation between the three gene mutant ation and the ubiquitin-proteasomes system.