Abstract: KCNK channels are new types of potassium channels which have four transmembrane segments and two pore domains.They are widely distributed in excitable and non-excitable tissues.There are three kinds of them in heart,including TWIK,TASK and TREK.KCNK channels are not sensitive to some classical blockers of potassium channels,but mechanical stimuli,unsaturated fatty acid,pH and volatile anesthetics can regulate their activities.KCNK channels,acting as background potassium channels in cardiac myocytes,play an important role in regulating the time course,magnitude of the platform phase of action potentials and in maintaining resting potentials.