百令胶囊对多囊卵巢综合征代谢指标的影响

doi:10.3969/j.issn.1006-7795.2016.04.005

首都医科大学学报 ›› 2016, Vol. 37 ›› Issue (4): 437-443.doi: 10.3969/j.issn.1006-7795.2016.04.005

百令胶囊对多囊卵巢综合征代谢指标的影响

李扬璐¹, 阮祥燕^1,2, 赵越¹, 杜娟¹, 王利娟¹, 崔亚美¹, Alfred O. Mueck^1,2

1. 首都医科大学附属北京妇产医院内分泌科, 北京 100026;
2. 德国图宾根大学妇产医院绝经内分泌中心, 图宾根 D-72076, 德国

收稿日期:2016-06-15 出版日期:2016-08-21 发布日期:2016-07-18
通讯作者: 阮祥燕 E-mail:ruanxiangyan@163.com
基金资助:
北京市自然科学基金（Y161011），北京市卫生系统高层次卫生技术人才（2014-2-016），国家外国专家局2016年度北京市引进国外技术、管理人才项目（高外端）（20161100031），首都医科大学附属北京妇产医院、北京妇幼保健院学科带头人项目（2013-1）。

Effects of Bailing capsules on metabolism in patients with polycystic ovary syndrome

Li Yanglu¹, Ruan Xiangyan^1,2, Zhao Yue¹, Du Juan¹, Wang Lijuan¹, Cui Yamei¹, Alfred O. Mueck^1,2

1. Department of Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China;
2. Section of Endocrinology and Menopause, Department of Women's Health, University of Tubingen, Tubingen D-72076, Germany

Received:2016-06-15 Online:2016-08-21 Published:2016-07-18
Supported by:
This study was supported by Natural Science Foundation of Beijing(Y161011);Beijing Municipality Health Technology High-level Talent(2014-2-016);Foreign Technical and Administrative Talent Introduction Project in 2016,State Administration of Foreign Experts Affairs,the P. R. of China(20161100031);Project of Discipline Leader,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing Maternal and Child Health Care Hospital(2013-1).

摘要/Abstract

摘要： 目的观察百令胶囊辅助治疗多囊卵巢综合征（polycystic ovary syndrome，PCOS）的疗效，研究其对糖脂代谢和肝肾功能的影响。方法将90例PCOS患者采用随机数字表法随机分为研究组（50例）和对照组（40例）。研究组采用达英-35联合百令胶囊，对照组单用达英-35，观察并比较两组治疗3个月前后空腹血糖（fasting plasma glucose，FPG）、空腹胰岛素[fasting insulin，INS（OH）]、总胆固醇（total cholesterol，TC）、三酰甘油（triglyceride，TG）、高密度脂蛋白胆固醇（high density lipoprotein-cholesterol，HDL-C）、低密度脂蛋白胆固醇（low density lipoprotein-cholesterol，LDL-C）、载脂蛋白AI（apolipoprotein AI，Apo AI）、载脂蛋白B（apolipoprotein B，Apo B）、脂蛋白a[lipoprotein a，Lp（a）]、丙氨酸氨基转移酶（alanine aminotransferase，ALT）、门冬氨酸氨基转移酶（aspartate aminotransferase，AST）、r-谷氨酰转移酶（gamma-glutamyl transpeptidase，GGT）、血肌酐（creatinine，Cr）、尿素氮（blood urea nitrogen，BUN）、尿酸（uric acid，UA）等一系列代谢指标的变化。结果 ①治疗后两组TC均升高（P<0.05），HDL-C轻度升高（P>0.05）；研究组TG浓度较对照组低（P<0.05）；研究组治疗前后LDL-C差异无统计学意义，对照组显著下降（P<0.05）；治疗后两组Apo AI、Apo B均升高，Lp（a）降低（P<0.05），组间比较差异无统计学意义（P>0.05）。②研究组FPG、胰岛素抵抗较前降低（P<0.05），空腹胰岛素轻度降低（P>0.05）；研究组上述指标均较对照组低（P<0.05）。③与治疗前相比，研究组Cr和BUN差异无统计学意义（P>0.05），UA降低（P<0.05），对照组上述指标治疗前后差异无统计学意义（P>0.05）；治疗后研究组UA较对照组明显降低，其余指标组间比较差异无统计学意义。④肝功能指标在组内和组间比较差异无统计学意义。结论达英-35联合百令胶囊治疗PCOS患者能够改善糖代谢和胰岛素抵抗，对脂代谢有良好作用，保护肾功能，且对肝功能无不良影响。因此，百令胶囊能够作为治疗PCOS的辅助用药。

关键词: 多囊卵巢综合征, 百令胶囊, 达英-35, 糖代谢, 尿酸

Abstract: Objective To observe the efficacy of Bailing capsules on polycystic ovary syndrome (PCOS), and to investigate its effects on glucose and lipid metabolism, liver and renal function. Methods A total of 90 PCOS patients were divided into study group (n=50) and control group(n=40). Study group was treated with Diane-35 combined with Bailing capsules, while control group was treated with Diane-35 alone. Parameters of glucose and lipid metabolism, liver and renal functions were analyzed and compared between the two groups before and after treatment. Results ① Total cholesterol significantly increased and HDL-C increased without significant difference after treatment; compared with control group, triglyceride in study group did not increase but increased in control group; Apo AI, Apo B increased and Lp(a) decreased significantly after treatment in both groups, but without significant differences between the two groups. ② Fasting glucose, insulin and HOMA-IR decreased more in study group than those in the control group after treatment. ③ There was no significant difference in creatinine and blood urea nitrogen after treatment, but uric acid decreased more than that before treatment in the study group. The parameters of renal function in control group changed without significant differences. ④ Parameters of liver function between the two groups before and after treatment had no significant differences. Conclusion Diane-35 combined with Bailing capsules can improve the glucose and lipid metabolism and insulin resistance, and protect renal function, and did not have negative effect on liver function. Therefore, Bailing capsules is effective and safe for PCOS patients.

Key words: polycystic ovary syndrome, Bailing capsule, Diane-35, glucose metabolism, uric acid

中图分类号:

R711.75

李扬璐, 阮祥燕, 赵越, 杜娟, 王利娟, 崔亚美, Alfred O. Mueck. 百令胶囊对多囊卵巢综合征代谢指标的影响[J]. 首都医科大学学报, 2016, 37(4): 437-443.

Li Yanglu, Ruan Xiangyan, Zhao Yue, Du Juan, Wang Lijuan, Cui Yamei, Alfred O. Mueck. Effects of Bailing capsules on metabolism in patients with polycystic ovary syndrome[J]. Journal of Capital Medical University, 2016, 37(4): 437-443.

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百令胶囊对多囊卵巢综合征代谢指标的影响

Effects of Bailing capsules on metabolism in patients with polycystic ovary syndrome

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