XRCC1基因Arg280His多态与肺癌易感性关系的Meta分析

doi:10.3969/j.issn.1006-7795.2016.06.008

首都医科大学学报 ›› 2016, Vol. 37 ›› Issue (6): 758-762.doi: 10.3969/j.issn.1006-7795.2016.06.008

XRCC1基因Arg280His多态与肺癌易感性关系的Meta分析

谭晓刚, 王若天, 姚舒洋, 支修益

首都医科大学宣武医院胸外科首都医科大学肺癌中心, 北京 100053

收稿日期:2016-10-03 出版日期:2016-12-21 发布日期:2016-12-16
通讯作者: 支修益 E-mail:xiuyizhi2015@163.com
基金资助:
国家自然科学基金青年科学基金项目（81101773），北京市自然科学基金（7132106），首都医科大学基础-临床科研合作基金（14JL25，16JL67）资助

Meta analysis of the association between the polymorphism of XRCC1 Arg280His and lung cancer susceptibility

Tan Xiaogang, Wang Ruotian, Yao Shuyang, Zhi Xiuyi

Department of Thoracic Surgery, Xuanwu Hospital, Capital Medical University, Lung Cancer Center of Capital Medical University, Beijing 100053, China

Received:2016-10-03 Online:2016-12-21 Published:2016-12-16
Supported by:
This study was supported by National Natural Science Foundation of China(81101773), Natural Science Foundation of Beijing(7132106), Capital Medical University Foundation-Clinical Research Cooperation Fund(14JL25,16JL67).

摘要/Abstract

摘要： 目的综合评价XRCC1 Arg280His多态与肺癌易感性的关系。方法检索中国学术期刊文献数据库和Pubmed，查找有关XRCC1 Arg280His多态与肺癌易感性的关系的病例对照研究，并用Meta分析的方法分析XRCC1 Arg280His多态与肺癌易感性的关系，然后进行亚组分析、敏感性分析和文献的发表偏倚检验。结果本次Meta分析共纳入14篇文献，累计病例数5 711例，对照6 202例，显性模型下His/His+Arg/His基因型相对于Arg/Arg基因型的OR值为0.97，95%可信区间为0.78~1.22，无统计学意义关系。结论 XRCC1 Arg280His多态与肺癌易感性无统计学意义关系。

关键词: XRCC1 Arg280His, 多态, 肺癌, Meta分析

Abstract: Objective To evaluate the association between XRCC1 Arg280His and lung cancer susceptibility. Methods To collect the reports of case-control studies on the association between XRCC1 Arg280His and lung cancer susceptibility, we searched CNKI and Pubmed, then evaluated the association of XRCC1 Arg280His and lung cancer susceptibility by Meta analysis. Then we performed subgroup analysis and sensitivity analysis and publication bias test. Results There were 14 studies with 5 711 cases and 6 202 controls enrolled in this Meta-analysis. The pooled OR of His/His+Arg/His genotype compared to Arg/Arg genotype under dominant model was 0.97 without statistically significant association (95%CI:0.78-1.22). Conclusion The XRCC1 Arg280His polymorphism was not statistically significantly associated with the lung cancer susceptibility.

Key words: XRCC1 Arg280His, polymorphism, lung cancer, Meta analysis

中图分类号:

R734.2

谭晓刚, 王若天, 姚舒洋, 支修益. XRCC1基因Arg280His多态与肺癌易感性关系的Meta分析[J]. 首都医科大学学报, 2016, 37(6): 758-762.

Tan Xiaogang, Wang Ruotian, Yao Shuyang, Zhi Xiuyi. Meta analysis of the association between the polymorphism of XRCC1 Arg280His and lung cancer susceptibility[J]. Journal of Capital Medical University, 2016, 37(6): 758-762.

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XRCC1基因Arg280His多态与肺癌易感性关系的Meta分析

Meta analysis of the association between the polymorphism of XRCC1 Arg280His and lung cancer susceptibility

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