基于图论的戈谢病患儿静息态功能脑网络分析

doi:10.3969/j.issn.1006-7795.2018.02.003

首都医科大学学报 ›› 2018, Vol. 39 ›› Issue (2): 167-172.doi: 10.3969/j.issn.1006-7795.2018.02.003

• 影像新技术的临床与科研应用 • 上一篇下一篇

基于图论的戈谢病患儿静息态功能脑网络分析

张苗¹, 汪胜佩², 胡迪¹, 康惠颖¹, 何晖光², 彭芸¹

1. 首都医科大学附属北京儿童医院放射科国家儿童医学中心, 北京 100045;
2. 中国科学院自动化研究所, 北京 100190

收稿日期:2018-02-27 出版日期:2018-03-21 发布日期:2018-04-14
通讯作者: 彭芸 E-mail:cjr.likuncheng@vip.163.com
基金资助:
北京市医院管理局重点医学专业发展计划（ZYLX201609），北京市医院管理局临床医学发展专项经费资助（ZYLX201706），首都临床特色应用研究与成果推广项目（Z161100000516087）。

Graph theory-based analysis of brain functional networks in children with Gaucher disease

Zhang Miao¹, Wang Shengpei², Hu Di¹, Kang Huiying¹, He Huiguang², Peng Yun¹

1. Department of Radiology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China;
2. Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China

Received:2018-02-27 Online:2018-03-21 Published:2018-04-14
Supported by:
This study was supported by Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support(ZYLX201609),Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support(ZYLX201706),Capital Clinical Featured Applied Research and Achievements Popularization Project(Z161100000516087).

摘要/Abstract

摘要： 目的研究戈谢病（Gaucher disease，GD）患儿静息态功能网络拓扑属性的变化，并分析其与各临床参数之间的相关性。方法选择16例临床确诊为GD的患儿和16例性别、年龄相匹配的健康对照儿童。所有受试者均采集3D-T1结构数据及静息态脑功能数据，利用图论分析脑网络拓扑属性的变化，两组之间的比较采用双样本t检查，发生显著变化的拓扑属性与临床参数（年龄、发病年龄、病程、治疗时间）进行Pearson相关性分析。结果与健康对照组比较，GD患儿组的全局拓扑属性没有显著性变化；右侧额中回节点度显著性降低，右侧额中回、左侧额下回/眶额回、左侧顶上回/顶下回/楔前叶/角回节点效率显著性降低，这些脑区均位于执行控制网络；丢失2个核心节点，即楔前叶、左侧丘脑，新出现3个核心节点，即右侧角回/枕中回、右侧丘脑/尾状核/壳、右顶下小叶。这些脑区的拓扑属性与临床参数间未发现显著性相关。结论 GD患儿全局拓扑属性保持稳定，执行控制网络的部分脑区节点功能下降，部分核心节点发生自适应性再分布，该研究可为GD患儿脑功能损伤提供神经影像学证据。

关键词: 戈谢病, 磁共振成像, 图论

Abstract: Objective To investigate the topological properties of brain functional networks in children with Gaucher disease (GD) and analyze their correlation with clinical parameters. Methods Sixteen children diagnosed as GD and sixteen age-and sex-matched healthy controls (HCs) were recruited. 3DT1-weighted anatomical images and resting state functional magnetic resonance imaging (MRI) data of all participants were obtained. A two sample t-test was used to analyze the differences between the children with type 1 GD and HCs. The Pearson test was used to analyze the correlation between the altered properties and the clinical parameters. Results Compared with HCs, no significant alterations of global topological properties were found in GD patients. Right middle frontal gyrus also showed decreased nodal degree, and right middle frontal gyrus, left inferior frontal gyrus/orbitofrontal gyrus, and left superior parietal gyrus/inferior parietal gyrus/precuneus/angular gyrus showed decreased efficiency. All the functional regions of interests (ROIs) were components of executive control network (ECN). Two brain hubs lost and they were left thalamus and precuneus. Three brain hubs appeared and they were right thalamus/caudate/putamen, right angular gyrus/middle occipital gyrus and right inferior parietal lobule. Conclusion The efficiency of global topological properties in children with GD is preserved. Only functional ROIs within ECN showed decreased performance and a few brain hubs reorganized. Our result provided neuroimaging evidence for brain functional impairment in children with GD.

Key words: Gaucher disease, magnetic resonance imaging, graph theory

中图分类号:

R445.2

张苗, 汪胜佩, 胡迪, 康惠颖, 何晖光, 彭芸. 基于图论的戈谢病患儿静息态功能脑网络分析[J]. 首都医科大学学报, 2018, 39(2): 167-172.

Zhang Miao, Wang Shengpei, Hu Di, Kang Huiying, He Huiguang, Peng Yun. Graph theory-based analysis of brain functional networks in children with Gaucher disease[J]. Journal of Capital Medical University, 2018, 39(2): 167-172.

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基于图论的戈谢病患儿静息态功能脑网络分析

Graph theory-based analysis of brain functional networks in children with Gaucher disease

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