消化道巨噬细胞的功能与炎性肠病和肠道肿瘤的相关性研究进展

doi:10.3969/j.issn.1006-7795.2019.06.029

摘要/Abstract

摘要： 巨噬细胞（macrophages，Mφ）是由血液中的单核细胞（monocytes，Mo）分化而来，依据肠道环境的变化可分化为M1Mφ、M2Mφ和调节性Mφ（regulatory macrophages，Mregs），能够识别并杀死病原体，参与固有免疫与获得性免疫，常存在于免疫防御的部位。在正常情况下，Mφ具有保护肠免受炎性反应损害的重要作用，可产生多种抗炎细胞因子。除此之外，Mφ在维持肠内稳态方面起着至关重要的作用，当Mφ功能紊乱时多伴有肠道疾病的发生，如炎性肠病和胃肠肿瘤的发病。总之，Mφ对维持肠道健康的作用不容小视。

关键词: 巨噬细胞, 生物学特性, 免疫调节, 胃肠道疾病

Abstract: Macrophage (Mφ) is differentiated from mononuclear cells (Mo) in the blood, and it can be polarized into M1Mφ,M2Mφ and Mreg. Mφ can identify and eliminate pathogens. Mφ is involved in innate and acquired immunity, as it accumulates in the immune defense system. With a complex mechanism, Mφ protects the gut from inflammatory damage through producing anti-inflammatory cytokines. Mφ also plays a vital role in maintaining gastrointestinal homeostasis. More importantly, the imbalance of Mφ function may induce some intestinal diseases such as inflammatory bowel disease and gastrointestinal tumor. In short, the effect of Mφ on intestinal health should not be underestimated.

Key words: macrophage, biological characteristics, immunomodulation, gut diseases

中图分类号:

R333.3

王田田, 高琛琛, 李利生, 徐敬东. 消化道巨噬细胞的功能与炎性肠病和肠道肿瘤的相关性研究进展[J]. 首都医科大学学报, 2019, 40(6): 972-981.

Wang Tiantian, Gao Chenchen, Li Lisheng, Xu Jingdong. Research progress on the correlation between the function of gut macrophages and inflammatory bowel disease and intestinal tumors[J]. Journal of Capital Medical University, 2019, 40(6): 972-981.

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