老年急性单纯性创伤性脑损伤患者凝血指标与进展性出血性损伤的相关性

doi:10.3969/j.issn.1006-7795.2020.02.028

首都医科大学学报 ›› 2020, Vol. 41 ›› Issue (2): 302-306.doi: 10.3969/j.issn.1006-7795.2020.02.028

老年急性单纯性创伤性脑损伤患者凝血指标与进展性出血性损伤的相关性

胡悦¹, 宋灏哲², 陈佳树³, 梁雨婷⁴, 赵安琪⁵, 王沐榕⁴, 李力卓⁶

1. 首都医科大学第一临床医学院急诊专业, 北京 100053;
2. 首都医科大学第一临床医学院15级长学制临床医学专业, 北京 100053;
3. 首都医科大学第一临床医学院15级长学制临床医学专业(儿科班), 北京 100053;
4. 首都医科大学第一临床医学院16级长学制临床医学专业(儿科班), 北京 100053;
5. 首都医科大学第一临床医学院16级长学制临床医学专业, 北京 100053;
6. 首都医科大学宣武医院急诊科, 北京 100053

收稿日期:2019-12-18 出版日期:2020-04-21 发布日期:2020-04-16
通讯作者: 李力卓 E-mail:lilizhuo66@aliyun.com
基金资助:
国家自然科学基金项目（81660329），首都医科大学本科生科研项目（XSKY2019）。

Correlation between coagulation and progressive hemorrhagic injury in elderly patients with acute traumatic brain injury

Hu Yue¹, Song Haozhe², Chen Jiashu³, Liang Yuting⁴, Zhao Anqi⁵, Wang Murong⁴, Li Lizhuo⁶

1. Graduate Student of Emergency Department, First Clinical Hospital of Capital Medical University, Beijing 100053, China;
2. 2015 Eight-Year Program of Clinical Medicine Major, First Clinical Hospital of Capital Medical University, Beijing 100053, China;
3. 2015 Eight-Year Program of Clinical Medicine Major(Pediatric Class), the First Clinical Hospital of Capital Medical University, Beijing 100053, China;
4. 2016 Eight-Year Program of Clinical Medicine Major(Pediatric Class), First Clinical Hospital of Capital Medical University, Beijing 100053, China;
5. 2016 Eight-Year Program of Clinical Medicine Major, First Clinical Hospital of Capital Medical University, Beijing 100053, China;
6. Emergency Department, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

Received:2019-12-18 Online:2020-04-21 Published:2020-04-16
Supported by:
This study was supported by National Natural Science Foundation of China（81660329），Undergraduate Research Project of Capital Medical University（XSKY2019）.

摘要/Abstract

摘要： 创伤性脑损伤（traumatic brain injury，TBI）是指外力导致的大脑的损伤，是致死率和致残率居全身创伤首位的疾病，进展性出血性损伤（progressive hemorrhagic injury，PHI）是其严重合并症之一，也是颅脑创伤患者死亡的主要原因，凝血功能紊乱是其发生的主要病理生理机制之一。随着人口老龄化，颅脑创伤患者中老年人的比例逐渐上升，同时年龄是进展性出血性损伤的危险因素，老年颅脑创伤患者更易发生进展性出血性损伤，一旦发生，其病情往往较非老年患者更严重，预后更差。因此，研究老年急性单纯性创伤性脑损伤患者凝血指标与进展性出血性损伤的相关性及各凝血指标对PHI的预测价值，有利于临床参考以早期发现，及时诊治。本文主要结合相关文献综述老年患者创伤性脑损伤后凝血指标与进展性出血性脑损伤的相关性研究进展。

关键词: 创伤性脑损伤, 进展性出血性损伤, 凝血, 老年

Abstract: Traumatic brain injury (TBI) refers to the brain injury caused by external force, As which is the disease with the highest fatality rate and disability rate in the whole body trauma. As one of its serious complications, progressive hemorrhagic injury(PHI) is the main cause of death in patients with craniocerebral trauma,and coagulation dysfunction is one of its main pathophysiological mechanisms. The proportion of elderly patients with craniocerebral trauma gradually increases with the aging of the population. Meanwhile, age is a risk factor for progressive hemorrhagic injury. Elderly patients with craniocerebral trauma are prone to suffering from progressive hemorrhagic injury,with worse state and prognosis than those of non-elderly patients once PHI occurs. Therefore, exploration of the correlation between coagulation indexes and progressive hemorrhagic injury in elderly patients with TBI and the predictive value of each coagulation index to PHI is conducive to clinical reference for early detection and timely diagnosis and treatment. In this paper, we reviewed the research progresses of coagulation disorder and progressive hemorrhagic brain injury after traumatic brain injury in the elderly.

Key words: traumatic brain injury(TBI), progressive hemorrhagic injury(PHI), coagulation, the elderly

中图分类号:

R651

胡悦, 宋灏哲, 陈佳树, 梁雨婷, 赵安琪, 王沐榕, 李力卓. 老年急性单纯性创伤性脑损伤患者凝血指标与进展性出血性损伤的相关性[J]. 首都医科大学学报, 2020, 41(2): 302-306.

Hu Yue, Song Haozhe, Chen Jiashu, Liang Yuting, Zhao Anqi, Wang Murong, Li Lizhuo. Correlation between coagulation and progressive hemorrhagic injury in elderly patients with acute traumatic brain injury[J]. Journal of Capital Medical University, 2020, 41(2): 302-306.

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老年急性单纯性创伤性脑损伤患者凝血指标与进展性出血性损伤的相关性

Correlation between coagulation and progressive hemorrhagic injury in elderly patients with acute traumatic brain injury

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