多潘立酮联合质子泵抑制剂对阻塞性睡眠呼吸暂停综合征伴发咽喉反流疾病的治疗效果评价

doi:10.3969/j.issn.1006-7795.2020.04.019

首都医科大学学报 ›› 2020, Vol. 41 ›› Issue (4): 613-616.doi: 10.3969/j.issn.1006-7795.2020.04.019

多潘立酮联合质子泵抑制剂对阻塞性睡眠呼吸暂停综合征伴发咽喉反流疾病的治疗效果评价

闫素英, 姚淋尹, 冯燕军, 李希平, 魏永祥

首都医科大学附属北京安贞医院耳鼻咽喉头颈外科北京市心肺血管疾病研究所, 北京 100029

收稿日期:2019-09-03 出版日期:2020-08-21 发布日期:2020-07-22
通讯作者: 魏永祥 E-mail:weiyongxiang@vip.sina.com
基金资助:
北京市医院管理局"登峰"计划专项（DFL20150602）。

Clinical efficacy and safety analysis of domperidone combined with PPI in the treatment of reflux disease accompanied by obstructive sleep apnea syndrome

Yan Suying, Yao Linyin, Feng Yanjun, Li Xiping, Wei Yongxiang

Department of Otolaryngology, Beijing Anzhen Hospital, Capital Medical University;Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China

Received:2019-09-03 Online:2020-08-21 Published:2020-07-22
Supported by:
This study was supported by Beijing Municipal Administration of Hospitals Ascent Plan(DFL20150602).

摘要/Abstract

摘要： 目的探究多潘立酮联合质子泵抑制剂治疗阻塞性睡眠呼吸暂停综合征伴发咽喉反流疾病的临床治疗效果和安全性。方法将2018年1月-2019年5月期间首都医科大学附属北京安贞医院收治的81例阻塞性睡眠呼吸暂停综合征伴发咽喉反流疾病患者，按照组间年龄、性别、睡眠呼吸暂停低通气指数（sleep apnea hypopnea index，AHI）频率匹配的原则分成治疗组与对照组。对照组采用奥美拉唑治疗，观察组采用多潘立酮联合奥美拉唑治疗，连续治疗6周后，比较两组的临床治疗效果、咽喉反流症状指数（reflux symptom index，RSI）、反流体征指数（reflux finding score，RFS）评分以及唾液胃蛋白酶浓度。结果观察组与对照组的临床总有效率分别为73.3%以及44.4%，观察组高于对照组（χ²=6.995，P<0.05）；两组患者的RSI和RFS评分、唾液胃蛋白酶浓度用药后均较用药前改善，而观察组改善较对照组明显（t=7.948、9.495、11.629，P<0.05）。结论多潘立酮联合奥美拉唑治疗阻塞性睡眠呼吸暂停伴发咽喉反流疾病治疗效果显著，较单用奥美拉唑能更好地促进了临床症状和体征恢复。

关键词: 多潘立酮, 奥美拉唑, 咽喉反流疾病, 阻塞性睡眠呼吸暂停综合征

Abstract: Objective To explore the clinical efficacy and safety of domperidone combined with omeprazole in the treatment of laryngopharyngeal reflux disease (LPRD)accompanied with obstructive sleep apnea syndrome (OSA). Methods Totally 81 patients with LPRD admitted to our hospital from January 2018 to May 2019 were randomly divided into observation group and control group. The control group was treated with omeprazole, while the observation group was treated with domperidone combined with omeprazole. After 6 weeks of continuous treatment, the clinical efficacy, reflux symptom index (RSI) and reflux finding score (RFS), and pepsin concentrations were compared with eath other between the two groups. Results The total clinical effective rate of the observation group and the control group were 73.3% and 44.4%, respectively. The observation group was significantly higher than the control group (χ²=6.995, P<0.05). The RFS scale scores and the salivary pepsin concentrations were all improved after treatment compared with those before treatment, while the improvement in the treatment group was more significant than that in the control group (t=7.948, 9.495, 11.629, P<0.05). Conclusion The efficacy of domperidone combined with omeprazole in the treatment of LPRD accompanied with OSA is significant. It promotes the recovery of clinical symptoms and signs, with high safety.

Key words: domperidone, omeprazole, laryngopharyngeal reflux disease, obstructive sleep apnea syndrome (OSA)

中图分类号:

R828.6

闫素英, 姚淋尹, 冯燕军, 李希平, 魏永祥. 多潘立酮联合质子泵抑制剂对阻塞性睡眠呼吸暂停综合征伴发咽喉反流疾病的治疗效果评价[J]. 首都医科大学学报, 2020, 41(4): 613-616.

Yan Suying, Yao Linyin, Feng Yanjun, Li Xiping, Wei Yongxiang. Clinical efficacy and safety analysis of domperidone combined with PPI in the treatment of reflux disease accompanied by obstructive sleep apnea syndrome[J]. Journal of Capital Medical University, 2020, 41(4): 613-616.

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多潘立酮联合质子泵抑制剂对阻塞性睡眠呼吸暂停综合征伴发咽喉反流疾病的治疗效果评价

Clinical efficacy and safety analysis of domperidone combined with PPI in the treatment of reflux disease accompanied by obstructive sleep apnea syndrome

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