微创减重手术对重度肥胖女性月经周期及生育功能的影响

doi:10.3969/j.issn.1006-7795.2021.02.006

首都医科大学学报 ›› 2021, Vol. 42 ›› Issue (2): 200-203.doi: 10.3969/j.issn.1006-7795.2021.02.006

微创减重手术对重度肥胖女性月经周期及生育功能的影响

李健^1#, 吴凤云^1#, 张能维², 廉东波², 樊庆², 许光中², 杜德晓², 孙志鹏², 杜燕敏², 白文佩^1,*

1.首都医科大学附属北京世纪坛医院妇产科,北京 100038;
2. 首都医科大学附属北京世纪坛医院减重外科, 北京 100038

收稿日期:2021-02-22 发布日期:2021-04-26
作者简介:^#共同第一作者
基金资助:
北京市医院管理中心“登峰”计划专项(DFL20190701),首都医科大学重点实验室开放研究课题(2018-KF09)

Effects of minimally invasive bariatric surgery on menstrual cycle and reproductive function in severely obese women

Li Jian^1#, Wu Fengyun^1#, Zhang Nengwei², Lian Dongbo², Fan Qing², Xu Guangzhong², Du Dexiao², Sun Zhipeng², Du Yanmin², Bai Wenpei^{1, *}

1. Department of Obstetrics and Gynecology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China;
2. Department of Bariatric Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China

Received:2021-02-22 Published:2021-04-26
Contact: ^*E-mail:baiwp@bjsjth.cn
Supported by:
This study was supported by Beijing Hospitals Authority “Ascent” Plan(DFL20190701),Open Research Project of Key Laboratory of Capital Medical University (2018-KF09).

摘要/Abstract

摘要： 目的评估微创减重手术对重度肥胖女性月经周期及生育力的影响。方法选择2015至2019年在首都医科大学附属北京世纪坛医院减重外科行微创减重手术的肥胖女性患者55名,随访患者术后1、3、6、12个月体质量、月经周期、妊娠等信息,有生育要求者随访至分娩结束,比较患者术前及术后体质量、月经周期、妊娠率的差异。结果术前平均年龄(27.82±5.16)岁,平均体质量(108.85±20.84) kg,平均体质量指数(39.42±7.39) kg/m²,术前月经紊乱率为70.91%(39/55)。术中行袖状胃切除术者占87.27%(48/55),行胃旁路术者占12.73%(7/55)。术后随访中位时间为35个月(13~67)个月。术后1个月体质量下降最明显,平均减重(11.21±5.16) kg(-10.18%),术后6个月平均减重(29.79±10.28) kg(-26.94%),术后1年平均减重(34.15±12.72) kg(-30.56%),术后1年体质量指数降至(27.09±4.25) kg/m²。术后月经紊乱改善率为71.79%(28/39),月经恢复中位时间术后1.5(0.5~8.0)个月,总体月经紊乱率降至20%(11/55)。不孕症改善率为54.17%(13/24)。术后分娩者,妊娠距离手术平均时间(24.06±14.91)个月,分娩距离手术平均时间(33.21±15.17)个月,新生儿出生平均体质量(2.89±1.68) kg。结论微创减重手术可以明显改善重度肥胖女性的月经周期,提高受孕率,术后2年妊娠不影响新生儿体质量。

关键词: 微创减重手术, 肥胖, 月经紊乱, 妊娠

Abstract: Objective To evaluated the impact of minimally invasive bariatric surgery on menstrual cycle and fertility of severely obese women.Methods A total of 55 obese women who underwent minimally invasive bariatric surgery in our hospital from 2015 to 2019 were enrolled. The information of menstrual cycle, weight, pregnancy at 1, 3, 6 and 12 months after surgery were followed up, and those with fertility requirements were followed up to the end of delivery. The differences of weight, menstrual cycle and pregnancy rate before and after operation were compared. Results At baseline, the average age was (27.82±5.16) years old, the average body mass index (BMI) was (39.42±7.39) kg/m², and the average body weight was (108.85±20.84) kg. The rate of menstrual disorder was 70.91%(39/55). The rate of sleeve gastrectomy and gastric bypass was 87.27% and 12.73%, respectively. The median follow-up time was 35(13-67) months. The most obvious weight loss occurred in the first month after surgery, with an average weight loss of (11.21±5.16) kg (-10.18%). At 6 months and one year after surgery, the average weight loss were (29.79±10.28) kg (-26.94%) and (34.15±12.72) kg (-30.56%) respectively, and the BMI dropped to (27.09±4.25) kg/m² one year after surgery. The improvement rate of menstrual disorder was 71.79%(28/39). The median time of menstruation recovery was 1.5(0.5-8.0)months after operation, and the overall menstrual disorder rate decreased to 20%(11/55). The improvement rate of infertility was 54.17% (13/24). The average time of pregnancy and delivery after operation was (24.06±14.91) months and (33.21±15.17) months, respectively, and the average birth weight was (2.89±1.68) kg. Conclusion Minimally invasive bariatric surgery significantly improved the menstrual cycle and pregnancy rate of women with severe obesity. Pregnancy within two years after minimally invasive surgery did not affect the weight of the newborn.

Key words: minimally invasive bariatric surgery, obesity, menstrual disorder, pregnancy

中图分类号:

R711

李健, 吴凤云, 张能维, 廉东波, 樊庆, 许光中, 杜德晓, 孙志鹏, 杜燕敏, 白文佩. 微创减重手术对重度肥胖女性月经周期及生育功能的影响[J]. 首都医科大学学报, 2021, 42(2): 200-203.

Li Jian, Wu Fengyun, Zhang Nengwei, Lian Dongbo, Fan Qing, Xu Guangzhong, Du Dexiao, Sun Zhipeng, Du Yanmin, Bai Wenpei. Effects of minimally invasive bariatric surgery on menstrual cycle and reproductive function in severely obese women[J]. Journal of Capital Medical University, 2021, 42(2): 200-203.

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微创减重手术对重度肥胖女性月经周期及生育功能的影响

Effects of minimally invasive bariatric surgery on menstrual cycle and reproductive function in severely obese women

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