白细胞介素-6和超敏C反应蛋白与围产期颅内静脉窦血栓的相关性研究

doi:10.3969/j.issn.1006-7795.2021.02.008

摘要/Abstract

摘要： 目的探讨白细胞介素-6(interleukin-6,IL-6)和超敏C反应蛋白(hypersensitive C-reactive protein,Hs-CRP)与围产期颅内静脉窦血栓(cerebral venous sinus thrombosis,CVST)形成的相关性。方法选取2010年1月至2020年1月在首都医科大学宣武医院住院并诊断为CVST的孕产妇共39例,选取同期的孕产妇80例为对照组,检测CVST组急性期及恢复期IL-6和Hs-CRP的值,分析IL-6和Hs-CRP与围产期CVST形成的关系。结果 CVST组急性期IL-6和Hs-CRP浓度较对照组高,两组比较差异有统计学意义(P<0.05);CVST组急性期IL-6和Hs-CRP浓度高于恢复期,差异具有统计学意义(P<0.05);多因素Logistic回归分析显示,CVST发病与IL-6浓度升高呈正相关,(OR=4.280,95%CI为1.790~10.232),而与Hs-CRP浓度无关,(OR=0.930,95%CI为0.830~1.042)。结论当具有高危因素的孕产妇出现IL-6和Hs-CRP升高,尤其IL-6的升高时,应警惕CVST的发生;CVST发病急性期血浆IL-6、Hs-CRP均会出现明显升高,经有效治疗到恢复期炎性因子表达逐渐下降趋于正常,可评判疾病的短期预后。

关键词: 炎性反应因子, 白细胞介素-6, 超敏C反应蛋白, 颅内静脉窦血栓, 围产期

Abstract: Objective To investigate the correlation between inflammatory cytokines including interleukin-6 (IL-6), hypersensitive C-reactive protein (Hs-CRP) and cerebral venous sinus thrombosis (CVST) during perinatal period.Methods A total of 39 cases of pregnant and puerperal women diagnosed with CVST who were hospitalized in Xuanwu Hospital, Capital Medical University from January 2010 to January 2020 were retrospectively analyzed, and 80 cases were randomly selected as the control group. The values of IL-6 and Hs-CRP in the acute and convalescence stages of CVST group were detected, and the relationship between IL-6, Hs-CRP in the perinatal period and the formation of CVST was analyzed. Results IL-6 and hs-CRP were higher in CVST group, than those in control group and there was statistical difference between the two groups (P<0.05). The level of IL-6 and hs-CRP in the acute stage were significantly higher than that in the recovery stage, and the difference was statistically significant (P<0.05). The results of the multivariate Logistic regression analysis indicated that the high level of IL-6 was positively correlated with CVST. (OR=4.280,95%CI 1.790-10.232). However,there was no significant correlation with Hs-CRP(OR=0.930,95%CI=0.830-1.042).Conclusion When the level of IL-6 and hs-CRP, especially IL-6, increased in the pregnant women with risk factors, the occurrence of CVST should be vigilant.IL-6 and hs-CRP were significantly increased in the acute stage of CVST. After treatment, the expression of inflammatory factors gradually decreased and tended to be normal in the convalescence stage, which could be used to evaluate the short-term prognosis of the disease.

Key words: inflammatory cytokines, interleukin-6, hypersensitive C-reactive protein, cerebral venous sinus thrombosis, perinatal period

中图分类号:

张心红, 杨楚琪, 王轩, 沈霞光, 房纯, 王凤英. 白细胞介素-6和超敏C反应蛋白与围产期颅内静脉窦血栓的相关性研究[J]. 首都医科大学学报, 2021, 42(2): 210-213.

Zhang Xinhong, Yang Chuqi, Wang Xuan, Shen Xiaguang, Fang Chun, Wang Fengying. Correlation of interleukin-6 and hypersensitive C-reactive protein with cerebral venous and sinus thrombosis in perinatal stage[J]. Journal of Capital Medical University, 2021, 42(2): 210-213.

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