黄芩苷在呼吸道黏膜慢性炎症性疾病中的抗炎作用及机制研究进展

doi:10.3969/j.issn.1006-7795.2022.06.016

首都医科大学学报 ›› 2022, Vol. 43 ›› Issue (6): 919-923.doi: 10.3969/j.issn.1006-7795.2022.06.016

黄芩苷在呼吸道黏膜慢性炎症性疾病中的抗炎作用及机制研究进展

杨婧兴^1,2,3, 蔡超³, 赵妍^1,2, 王向东^1,2, 张罗^1,2,4,5

1.首都医科大学附属北京同仁医院耳鼻咽喉头颈外科,北京100730;
2.北京市耳鼻咽喉科研究所,北京100005;
3.首都医科大学附属北京佑安医院耳鼻咽喉科,北京100069;
4.首都医科大学附属北京同仁医院变态反应科,北京100730;
5.中国医学科学院慢性鼻病诊疗策略研究创新单元,北京 100005

收稿日期:2022-09-06 出版日期:2022-12-21 发布日期:2022-11-30
基金资助:
教育部长江学者创新团队(IRT13082),中国医学科学院医学与健康科技创新工程项目(2019-I2M-5-022),北京市科技计划首都健康保障培育研究项目(Z181100001618002)。

Research advances in the anti-inflammatory effects and mechanisms of baicalin in chronic inflammatory diseases of respiratory mucosa

Yang Jingxing^1,2,3, Cai Chao³, Zhao Yan^1,2, Wang Xiangdong^1,2, Zhang Luo^1,2,4,5

1. Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China;
2. Beijing Institute of Otorhinolaryngology, Beijing 100005, China;
3. Department of Otorhinolaryngology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China;
4. Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing 100730 China;
5. Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences, Beijing 100005, China

Received:2022-09-06 Online:2022-12-21 Published:2022-11-30
Contact: ^*E-mail:dr.luozhang@139.com

摘要/Abstract

摘要： 黄芩苷是源于中药黄芩根部的黄酮类化合物,是黄芩的主要活性成分,其药理作用广泛,具有良好的抗炎、抗癌、抗病毒和抗氧化等作用。以慢性鼻窦炎、过敏性鼻炎和哮喘为主的呼吸道黏膜慢性炎症性疾病是影响人类日常生活的严重慢性疾病之一,其发病机制复杂,目前对于此类疾病的治疗易产生不良反应且有一定的局限性。中药成分黄芩苷因其抗炎效果好,不良反应小而具有开发为治疗呼吸道黏膜慢性炎症性疾病的药物潜能。本文对黄芩苷在呼吸道黏膜慢性炎症性疾病中的抗炎作用及机制研究进展进行总结和归纳,为其在相关疾病的临床应用提供理论依据。

关键词: 黄芩苷, 呼吸道黏膜慢性炎症, 抗炎作用, 研究进展

Abstract: Baicalin is a kind of flavonoid component derived from the root of Scutellaria baicalensis, the main active ingredient of the plant. It has a wide range of pharmacological effects such as anti-inflammatory, anti-cancer, antiviral and antioxidant effects.Chronic inflammatory diseases of the respiratory mucosa, mainly chronic rhinosinusitis, allergic rhinitis and asthma, are among the serious chronic diseases affecting human daily life. The pathogenesis is complex and the current therapeutic methods have certain limitations and adverse effects.The traditional Chinese medicine baicalin has the potential to be developed as a drug for the treatment of chronic inflammatory diseases of the respiratory mucosa because of its good anti-inflammatory effect and low toxic side effects.In this review, we summarize the anti-inflammatory mechanism of baicalin in chronic inflammatory diseases of the respiratory mucosa and provide theoretical basis for its clinical application in related diseases.

Key words: baicalin, chronic inflammation of respiratory mucosa, anti-inflammatory effect, research advances

中图分类号:

R765

杨婧兴, 蔡超, 赵妍, 王向东, 张罗. 黄芩苷在呼吸道黏膜慢性炎症性疾病中的抗炎作用及机制研究进展[J]. 首都医科大学学报, 2022, 43(6): 919-923.

Yang Jingxing, Cai Chao, Zhao Yan, Wang Xiangdong, Zhang Luo. Research advances in the anti-inflammatory effects and mechanisms of baicalin in chronic inflammatory diseases of respiratory mucosa[J]. Journal of Capital Medical University, 2022, 43(6): 919-923.

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黄芩苷在呼吸道黏膜慢性炎症性疾病中的抗炎作用及机制研究进展

Research advances in the anti-inflammatory effects and mechanisms of baicalin in chronic inflammatory diseases of respiratory mucosa

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