电针对新型抗精神病药物所致代谢综合征的干预效果

doi:10.3969/j.issn.1006-7795.2023.04.018

摘要/Abstract

摘要： 目的观察电针治疗对于新型抗精神病药物引起的代谢综合征(metabolic syndrome，MS)的疗效。方法将70例服用新型抗精神病药物所致MS患者，按照数字表法随机分为治疗组和对照组，每组各35例，对照组接受饮食及运动干预，治疗组在接受饮食及运动干预的同时采用电针治疗。观察两组患者在治疗前、治疗第28天和治疗第56天的腰围、体质量指数（body mass index,BMI）、血压、血脂、血糖的变化,并在治疗前后评定生活质量评价量表（Short Form 36-item Health Survey，SF-36）。结果治疗前两组患者各项指标差异均无统计学意义 (P>0.05 )。对照组治疗56 d后仅三酰甘油(triglyceride,TG)、餐后2 h血糖(2 h postprandial blood glucose,2hPG)较治疗前明显降低(P<0．05)，其余指标无明显变化，而治疗组在治疗后各时间点收缩压、舒张压、TG、高密度脂蛋白胆固醇(high density lipoprotein-cholesterol,HDL-C)、空腹血糖（fasting plasma glucose,FPG）及2hPG与治疗前相比，差异均有统计学意义(P<0.05)。治疗56 d后，治疗组患者的腰围、BMI与治疗前相比，差异均有统计学意义(P<0.05)。两两比较分析结果显示，在治疗56 d后，治疗组患者的腰围、BMI、收缩压、舒张压、TG、HDL-C、FPG及2hPG与对照组相比，差异均有统计学意义(P<0.05)。治疗后,与对照组相比，治疗组SF-36量表评分明显升高 ( P<0.05 )。结论电针治疗新型抗精神病药物所致MS患者的临床疗效较好，能降低患者的腰围、BMI、血压、血糖及血脂，明显改善生活质量，安全性好。

关键词: 电针, 新型抗精神病药物, 代谢综合征

Abstract: Objective To observe the effect of electroacupuncture on metabolic syndrome (MS) induced by new antipsychotics . Methods A total of 70 patients with MS caused by new antipsychotic drugs were selected and randomly divided into the treatment group (35 cases) and control group (35 cases) with the method of digital table.The control group received diet and exercise intervention, the treatment group also received electroacupuncture besides dietary and exercise interventions.The changes of waist circumference, body mass index (BMI), blood pressure, blood lipid and blood glucose between the two groups were compared before and after treatment. The Short Form 36-item Health Survey （SF-36） score was evaluated before and after treatment.Results There was no significant difference between the two groups for all indexes (P>0.05). After 56 d of treatment,only the triglyceride (TG) and 2 h postprandial blood glucose (2hPG) significantly decreased in the control group (P<0.05)，without significant change in other indexes(P>0.05). However, systolic blood pressure (SBP), diastolic blood pressure (DBP), TG, HDL-C， FPG and 2hPG of the treatment group at every time point after treatment were significantly different from those before treatment (P<0.05). After 56 d of treatment, the waist circumference and BMI of the treatment group were significantly different from those before treatment (P<0.05).Further analysis indicated that,after 56 d of treatment, the waist circumference, BMI, systolic blood pressure, diastolic blood pressure, triglyceride, high density lipoprotein cholesterol, fasting blood glucose and 2hPG of the treatment group were significantly different from those of the control group (P<0.05). After treatment, the SF-36 score in the treatment group was significantly higher than that in the control group (P<0.05).Conclusions The clinical effect of electroacupuncture in the treatment of metabolic syndrome caused by new antipsychotics is better, and electroacupuncture can reduce waist circumference, BMI, blood pressure, blood glucose and blood lipid. It obviously improved the quality of life with good safety.

Key words: electroacupuncture, new antipsychotics, metabolic syndrome

中图分类号:

R749.3

王群松, 于海燕, 季向东, 李苗, 蒋怡烨. 电针对新型抗精神病药物所致代谢综合征的干预效果[J]. 首都医科大学学报, 2023, 44(4): 614-619.

Wang Qunsong, Yu Haiyan, Ji Xiangdong, Li Miao, Jiang Yiye. Intervention effect of electroacupuncture on metabolic syndrome induced by new antipsychotics[J]. Journal of Capital Medical University, 2023, 44(4): 614-619.

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