单侧及双侧卵巢切除对大鼠脂肪组织及子宫质量的影响

doi:10.3969/j.issn.1006-7795.2023.04.003

首都医科大学学报 ›› 2023, Vol. 44 ›› Issue (4): 524-529.doi: 10.3969/j.issn.1006-7795.2023.04.003

• 妇科内分泌绝经与生育力保护 • 上一篇下一篇

单侧及双侧卵巢切除对大鼠脂肪组织及子宫质量的影响

杨瑜¹, 阮祥燕^1*, 程姣姣¹, 许新¹, Alfred O.Mueck^1，2

1.首都医科大学附属北京妇产医院/北京妇幼保健院内分泌科，北京 100026; 2.德国图宾根大学妇产医院妇女健康部与妇女健康研究中心，图宾根 D-72076，德国

收稿日期:2023-05-09 出版日期:2023-08-21 发布日期:2023-07-26
通讯作者: 阮祥燕 E-mail:ruanxiangyan@ccmu.edu.cn
基金资助:
北京市自然科学基金项目（7202047），北京市医院管理中心“登峰”人才培养计划项目（DFL20181401），首批北京市级妇幼保健专科示范单位“更年期保健专科”项目［（2017）35号］

Effects of unilateral and bilateral ovariectomy on adipose tissue and uterine weight in rats

Yang Yu¹， Ruan Xiangyan^1*， Cheng Jiaojiao¹， Xu Xin¹，Alfred O.Mueck^1，2

1.Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University/Beijing Maternal and Child Health Care Hospital, Beijing 100026, China； 2.Department of Women's Health, Research Centre for Women's Health and University Women's Hospital of Tuebingen, University Hospitals of Tuebingen, Tuebingen D-72076, Germany

Received:2023-05-09 Online:2023-08-21 Published:2023-07-26
Supported by:
This study was supported by Natural Science Foundation of Beijing (7202047)，Beijing Municipal Administration of Hospitals' Ascent Plan (DFL20181401)，the First Batch of Beijing Maternal and Child Health Specialist Demonstration Units “Menopausal Health Specialist”［( 2017) 35］.

摘要/Abstract

摘要： 目的观察单侧及双侧卵巢切除对大鼠脂肪组织及子宫质量的影响。方法 SD大鼠10~11周龄时，按照切除的卵巢数量分为3组：假手术组（sham operation，Sham）(n=5)，单侧卵巢切除组（unilateral ovariectomy, U-OVX）(n=5)，双侧卵巢切除组（bilateral ovariectomy, B-OVX）(n=6）。术后1年处死，比较组间肩胛间棕色脂肪组织（brown adipose tissue，BAT）、腹股沟皮下脂肪组织（subcutaneous adipose tissue，SAT）、腹腔内脏脂肪组织（intra-abdominal adipose tissue，IAAT）及子宫质量差异。结果 B-OVX组大鼠SAT和IAAT质量较Sham组增加。Sham组和U-OVX组的SAT、IAAT质量差异无统计学意义。三组间BAT质量差异无统计学意义。B-OVX组子宫质量小于Sham组和U-OVX组，U-OVX组子宫质量和Sham组相比差异无统计学意义。结论双侧卵巢切除后大鼠皮下脂肪和腹腔内脏脂肪增多，单侧卵巢切除不影响大鼠皮下脂肪和腹腔内脏脂肪质量。双侧卵巢及单侧卵巢切除均不影响棕色脂肪的质量。单侧卵巢切除并不会导致子宫萎缩。

关键词: 卵巢切除, 棕色脂肪, 皮下脂肪, 内脏脂肪, 绝经

Abstract: Objective To explore the effects of unilateral and bilateral ovariectomy on the weight of adipose tissue and uterus in rats. Methods SD rats aged 10-11 weeks were divided into three groups: sham operation (Sham, n=5), unilateral ovariectomy (U-OVX, n =5) and bilateral ovariectomy (B-OVX, n=6). The weight of interscapular brown adipose tissue (BAT), inguinal subcutaneous adipose tissue (SAT), intra-abdominal visceral adipose tissue (IAAT), and uterus were compared one year after operation. Results Compared with the Sham group, the weight of SAT and IAAT increased in B-OVX group. There was no difference between the Sham group and U-OVX group in SAT and IAAT weight. There was no difference in BAT weight among the three groups. The weight of uterus in B-OVX group was lower than that in the Sham group and U-OVX group, there was no difference between U-OVX group and Sham group. Conclusions Bilateral ovariectomy increased the weight of subcutaneous and intra-abdominal visceral adipose tissue, but unilateral ovariectomy did not affect the weight of subcutaneous and intra-abdominal visceral adipose tissue. Bilateral ovariectomy and unilateral ovariectomy didn't affect the weight of brown adipose. Unilateral ovariectomy did not cause uterine atrophy.

Key words: ovariectomy, brown adipose tissue, subcutaneous adipose tissue, visceral adipose tissue, menopause

中图分类号:

R711

杨瑜, 阮祥燕, 程姣姣, 许新, Alfred O.Mueck. 单侧及双侧卵巢切除对大鼠脂肪组织及子宫质量的影响[J]. 首都医科大学学报, 2023, 44(4): 524-529.

Yang Yu, Ruan Xiangyan, Cheng Jiaojiao, Xu Xin, Alfred O.Mueck. Effects of unilateral and bilateral ovariectomy on adipose tissue and uterine weight in rats[J]. Journal of Capital Medical University, 2023, 44(4): 524-529.

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单侧及双侧卵巢切除对大鼠脂肪组织及子宫质量的影响

Effects of unilateral and bilateral ovariectomy on adipose tissue and uterine weight in rats

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