首都医科大学学报 ›› 2005, Vol. 26 ›› Issue (3): 303-305.

• 论著·临床研究 • 上一篇    下一篇

儿童鞍区肿瘤术后低钠血症的治疗

贾旺, 马振宇, 毕智勇, 周强   

  1. 首都医科大学附属北京天坛医院神经外科
  • 收稿日期:2005-04-01 修回日期:1900-01-01 出版日期:2005-06-24 发布日期:2005-06-24

Treatment of Postoperative Hyponatremia in Children Associated with Sella Region Tumor

Jia Wang, Ma Zhenyu, Bi Zhiyong, Zhou Qiang   

  1. Department of Neurosurgery, Beijing Tiantan Hospital, Capital University of Medical Sciences
  • Received:2005-04-01 Revised:1900-01-01 Online:2005-06-24 Published:2005-06-24

摘要:

目的 研究儿童鞍区肿瘤术后低钠血症的发病机制、变化规律及其治疗措施.方法 对1997年4月至2002年10月间81例鞍区肿瘤术后并发低钠血症的患儿进行回顾性研究.记录手术当天及术后每天定时检测的血钠值及其相应的治疗措施.结果 450例鞍区肿瘤患儿术后81例出现单纯性血钠紊乱,轻度28例(34.6%),中度35例(43.2%),重度18例(22.2%).其中50.6%(41/81)出现于手术当天和术后第1天.48例(59.3%)有临床症状,26例(32.1%)出现意识障碍.83.9%(68/81)患儿于出现低钠血症后8 d内恢复正常.结论 儿童鞍区肿瘤术后低钠血症主要原因是抗利尿激素分泌不当综合征(syndrome of inappropriate antidiwetic hormone secretion, SIADH)或脑性耗盐综合征(cerebral salt wasting syndrome, CSWS).掌握其发病机制可及时有效地纠正低血钠,缩短儿童鞍区肿瘤术后低钠血症的病理经过.

关键词: 儿童, 鞍区肿瘤, 低钠血症

Abstract:

Objective To investigate the etiology, regularity and treatment of postoperative hyponatremia of sella region tumor in children. Methods Clinical studies of 81 patients with postoperative hyponatremia of sella region tumor were reviewed retrospectively. Recording serum sodium on the operative day and postoperation daily, corresponding therapy according to the serum sodium and patient's condition was also recorded. Results Purely hyponatremia was observed in 81 of 450 cases. Mild moderate and severe cases hyponatremia were 28(34.6%), 35(43.2%) and 18(22.2%), respectively. 26 cases(32.1%)had disturbance of consciousness. 50.6%(41/81) was occurred on operative day and the first day after operation. 83.9%(68/81) was recovered within 8 d. Conclusion SIADH and CSWS are cardinal etiological factors of hyponatremia in children associated with sella tumor. Grasping the regularity and etiology can redress the sodium irregularity effectively and shorten the pathological process.

Key words: children, sella region tumor, hyponatremia

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