关键词: 直接凝血酶抑制剂, 生物学活性, 安全性, 临床应用

Abstract:

Direct thrombin inhibitors are newly emerging decoagulant.They inhibit thrombin,and also inhibits factor Ⅴ,Ⅷ,ⅩⅢ and fibrinogen.All of which are mediated by thrombin.Direct thrombin inhibitors not only have anticoagulant function,but also have anti-platelet aggregation function.So,they have a good perspective in treatment of some diseases related to thrombus formation.In the treatment and prevention of some diseases such as acute coronary syndromes,atrial fibrillation,venous thromboembolism,heparin induced thrombocytopenia, ischemic cerebrovascular diseases,peripheral arterial occlusion,as well as during percutaneous coronary intervention,the direct thrombin inhibitor plays a role.This paper reviews the role of direct thrombin inhibitors in different aspects such as biologic activity,and safety and their clinical applications.

Key words: direct thrombin inhibitor, biologic activity, security, clinical application