Journal of Capital Medical University ›› 2012, Vol. 33 ›› Issue (2): 214-217.doi: 10.3969/j.issn.1006-7795.2012.02.016

• 基础研究 • Previous Articles     Next Articles

Double negative T cells and lymphocyte subtype in chronic hepatitis C

LIANG Qi1, JIAO Yan-mei2, JI Yun-xia2, LI Tian2, WU Hao2, ZHANG Guo-yuan1, TANG Zhong1   

  1. 1. Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong 637100, China;2. Department of Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
  • Received:2011-11-25 Revised:1900-01-01 Online:2012-04-21 Published:2012-04-21

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Abstract: Objective To investigate the expression and significance of CD3+CD4-CD8-(double negative T, DNT) cells and T lymphocyte subsets in chronic hepatitis C cases. Methods DNT cells and lymphocyte subsets of peripheral blood were detected by flow cytometry in 92 chronic hepatitis C patients and 93 healthy people, the differences between them was comparatively analyzed. Results The percent of DNT cells(8.57%±6.16%) were higher in patients with chronic hepatitis C than those in normal control group(6.78%±4.50%)(P<0.05), However, there was no significant difference in the absolute value of DNT cells between them(P>0.05). The CD4 cells, the ratio of CD4+/CD8+ were decreased but CD8 cells increased in comparison with normal control group(P<0.001). Conclusion The significant increase of DNT cells and the change of T lymphocyte subsets's percentage in chronic hepatitis C patients might be one of the important reason for chronicity and long-term liver damage of hepatitis C.

Key words: chronic hepatitis C, double negative T cell, T lymphocyte subsets

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