Abstract: Objective To investigate synthesis of thymine nucleoside.Methods The reactions of phenyl 3,4,6-Tri-O-acetyl-2-deoxy-2-phthalimido-1-thio-β-glucopyranoside and phenyl 3,4-Di-O-benzoyl-6-O-acetyl-2-deoxy-2-phthalimido-1-thio-β-glucopyranoside with the silylated thymine were allowed to occur in dichlormethane. Results The 3,4,6-Tri-O-acetyl-2-deoxy-2-phthalimido-1-thio-β-glucopyranosideand phenyl 3,4-Di-O-benzoyl-6-O-acetyl-2-deoxy-2-phthalimido-1-thio-glucopyranoside reacted with the silylated thymine to form N-β-glycoside. Conclusion Thus we have explored the reaction glucopyranosides with thymine. phenyl 3,4,6-Tri-O-acetyl-2-deoxy-2-phthalimido-1-thio-β-glucopyranoside and phenyl 3,4-Di-O-benzoyl-6-O-acetyl-2-deoxy-2-phthalimido-1-thio-β-glucopyranoside furnished N¹-β-glycosideand N³-β-glycoside.

Key words: glucosamine, thymine, nucleoside