G protein coupled receptor, the vault of drug discovery——introduction of Nobel Prize in Chemistry 2012

doi:10.3969/j.issn.1006-7795.2012.05.029

Journal of Capital Medical University ›› 2012, Vol. 33 ›› Issue (5): 695-699.doi: 10.3969/j.issn.1006-7795.2012.05.029

• 诺贝尔奖 • Previous Articles Next Articles

G protein coupled receptor, the vault of drug discovery——introduction of Nobel Prize in Chemistry 2012

ZHANG Chen-guang, DING Wei

Department of Medical Genetics, Capital Medical University, Beijing 100069,China

Received:2012-10-14 Revised:1900-01-01 Online:2012-10-21 Published:2012-10-21

Abstract

Abstract: Two American scientists Robert Lefkowitz and Brian Kobilka have honored the 2012 Nobel Price in Chemistry for their achievements in the G protein coupled receptor (GPCR) studies. In this article, we introduced their research in the related fields and summarized their major academic contributions that recognized among scientific researchers. Furthermore, we expanded the discussion regarding the significance and the potential applications of their work for morden medication and drug development.

Key words: Nobel Prize in Chemistry, G protein coupled receptor, signal transduction, drug development, structural biology

ZHANG Chen-guang;DING Wei. G protein coupled receptor, the vault of drug discovery——introduction of Nobel Prize in Chemistry 2012[J]. Journal of Capital Medical University, 2012, 33(5): 695-699.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2012.05.029

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2012/V33/I5/695

[1]	Jiang Bingyin, Zhang Jiyi, Zhang Xiaoyi, Wang Yuji, Zhao Ming. Click chemistry and bioorthogonal chemistry: modular construction of the micro world——Introduction of the Nobel Prize in Chemistry 2022 [J]. Journal of Capital Medical University, 2022, 43(5): 807-812.
[2]	Li Yuanyuan, Feng Qiqi, Zhang Xiaoyi, Wang Yuji, Zhao Ming. Asymmetric organocatalysis: making pharmaceutical development simple—Introduction of the Nobel Prize in Chemistry 2021 [J]. Journal of Capital Medical University, 2021, 42(5): 883-887.
[3]	Gu Siyu, Yang Xiaomei, He Junqi. gene editing technology: gene scissors—a tool for rewriting the code of life—introduction of The Nobel Prize in Chemistry 2020 [J]. Journal of Capital Medical University, 2020, 41(6): 1014-1018.
[4]	Cao Lixue. Harnessing the power of evolution:directed evolution of enzymes and binding protein & Phage display-Introduction of Nobel prize in Chemistry 2018 [J]. Journal of Capital Medical University, 2018, 39(5): 770-777.
[5]	Yang Hui, Li Shentao, Xue Bing. Cryo-electron microscopy:capture life in atomic details-the 2017 Nobel Prize in Chemistry [J]. Journal of Capital Medical University, 2017, 38(5): 770-776.
[6]	Liu Quanle, Li Tianfu, Wang Baoguo. Neuroprotective mechanism of sodium valproate and its application [J]. Journal of Capital Medical University, 2017, 38(3): 365-371.
[7]	Kong Lu, Ding Wei. Mechanisms of DNA repair for the maintenance of genome stability in cells——introduction of 2015 Nobel Prize in Chemistry [J]. Journal of Capital Medical University, 2015, 36(5): 823-828.
[8]	WANG Fang;GUAN Yunqian. Role of the p16INK4a/p14ARF Gene in Cell Senescence and Tumor Suppression [J]. Journal of Capital Medical University, 2011, 32(1): 100-105.
[9]	LU Zhao;DING Wei. What You See Is What You Learn, What You Learn Guides What You Do——Introduction to the Contribution of the Awardees of Nobel Prize in Chemistry 2009 [J]. Journal of Capital Medical University, 2009, 30(5): 723-726.
[10]	Wang Hongxia;Zeng Xiangjun;Wang Jue;Lu Lingqiao;Mu Jing;Chang Jing;Zhang Like. Changes in Expression of UⅡ and Its Receptor in 2DM Mouse Liver [J]. Journal of Capital Medical University, 2008, 29(6): 741-744.
[11]	Meng Yan;Zhang Jingyan;Wang Rong;Sheng Shuli. Studies on PI3'K Signal Transduction Pathway in Human Neuroblastoma SY5Y Cells [J]. Journal of Capital Medical University, 2008, 29(2): 167-170.
[12]	Guo Qiyu;Gao Yan;Cong Lin;Shao Ningsheng. Effects of Leptin on Gene and Protein Expression and Tyrosine Phosphorylation of Leptin Receptor in Rat hepatocyte [J]. Journal of Capital Medical University, 2007, 28(3): 304-306.
[13]	Li Xianghui;Zhang Yuxiang;Jia Hongti . The Beauty of a Transcriptional Machine——The Nobel Prize in Chemistry for 2006 [J]. Journal of Capital Medical University, 2006, 27(6): 856-858.
[14]	Zhang Like;Liu Yuling;Lu Lingqiao;Yao Xinghai. Effects of RGDS Peptide on Aggregation and Phosphorylation of ERK1/2 in Rat Platelets in Vitro [J]. Journal of Capital Medical University, 2005, 26(3): 291-292.
[15]	Zhuang Xiaoming;Zhao Zhiwei;Ji Zhijuan;Zhao Yongmei;Sheng Shuli . Effect of APP17 Peptide on the Hippocampal Neurons Ultrastructure and Expression of InsR, Ins-1 in Type 2 Diabetic KKAy Mice [J]. Journal of Capital Medical University, 2002, 23(2): 115-118.

G protein coupled receptor, the vault of drug discovery——introduction of Nobel Prize in Chemistry 2012

PDF

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments