Expression of matrix metalloproteinase-3 in different sites of osteoarthritis of knee synovial membrane and clinical significance

doi:10.3969/j.issn.1006-7795.2013.03.017

Abstract

Abstract:

Objective To determine the expression intensity of matrix metalloproteinase-3 (MMP-3) in different sites of osteoarthritis of knee synovial membrane and to explore its relationship with the pathogenesis of KOA. Methods Forty-eight KOA patients treated in our hospital were chosen as study subject. Knee synovial membrane specimens were excised separately from medial compartment,supra-patellar bursa and the lateral compartment during arthroscopy. Clinical scores of these patients were assessed by the comprehensive score system. Through immunohistochemical staining,MMP-3 positive expression intensity was compared among different sites of KOA synovial membrane. Moreover,the correlation between MMP-3 positive expression intensity and clinical scores was analyzed.Results 1MMP-3 positive expression intensity was 3.45±0.22 for medial compartment synovial membrane,2.69±0.21 for supra-patellar bursa,and 1.99±0.16 for lateral compartment,with statistically significant difference (P<0.001). 2MMP-3 positive expression intensity in synovial membrane of medial compartment and supra-patellar bursa presented a positive correlation with clinical scores,and the correlation coefficients were r₁=0.894(P<0.001) and r₂=0.803(P<0.001). There was no significant correlation between clinical scores and the positive expression intensity of MMP-3 in the lateral compartment with r₃=0.485(P=0.057).Conclusion MMP-3 expression intensity in synovial membrane of medial compartment was the highest of the three sites,which coincided with the manifestation that medial part of the involved knee joint suffers the most severe symptom. The disease degree of synovial membrane was positively correlated with clinical scores,providing a basis for improving the joint function and relieving the knee pain through limited resection of diseased synovial membrane by arthroscopy in clinical work.

Key words: osteoarthritis of knee(KOA), synovial membrane, matrix metalloproteinase 3(MMP-3), clinical score

CLC Number:

R 684.3

Li Shoulong, Maimaiti·Aiyireti, PAN Haitao, ZENG Zheng. Expression of matrix metalloproteinase-3 in different sites of osteoarthritis of knee synovial membrane and clinical significance[J]. Journal of Capital Medical University, 2013, 34(3): 411-415.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2013.03.017

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2013/V34/I3/411

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