Interleukin-8-251T/A gene polymorphism and lung cancer susceptibility: a meta-analysis

doi:10.3969/j.issn.1006-7795.2014.06.007

Abstract

Abstract:

Objective To perform a meta-analysis to evaluate the association between the interleukin-8-251T/A(rs4073) gene polymorphism and lung cancer risk. Methods A literature search at PubMed was performed to identify case-control study articles published before December 1st, 2013. The Stata11.0 software was used to calculate the pooled odds ratios(OR) with 95% confidence intervals(CI). And the analysis was stratified by Asian and non-Asian populations. Results Totally six articles met our inclusion criteria. The included studies yielded a total of 3 265 lung cancer cases and 3607 controls. For the homozygous A/A and A allele carriers(T/A + A/A), the pooled ORs for all studies combining 3 265 cases and 3 607 controls were 1.03(95% CI=0.92-1.14, P=0.235 for heterogeneity) and 1.07(95% CI=0.96-1.19, P=0.245 for heterogeneity) when compared with the homozygous wild-type genotype(T/T). When the analysis was stratified by Asian and non-Asian populations, significant risks were found among Asians for both the A allele carriers(OR=1.48, 95% CI=1.04-2.11, P=0.030 for heterogeneity) and the homozygous A/A(OR=1.35, 95% CI=1.02-1.92, P=0.090 for heterogeneity) individuals. However, no significant associations were found in non-Asian populations using any of the genetic models. Conclusion This Meta-analysis suggests that the interleukin-8-251 allele confer an increased risk for the development of lung cancer among Asians.

Key words: interleukin-8, polymorphism, lung cancer, susceptibility, Meta-analysis

CLC Number:

R734.2

Zhen Dezhi, Wang Xiaobin, Li Yunsong, Li Jie, Han Yi, Liu Zhidong. Interleukin-8-251T/A gene polymorphism and lung cancer susceptibility: a meta-analysis[J]. Journal of Capital Medical University, 2014, 35(6): 711-716.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2014.06.007

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2014/V35/I6/711

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