Observation of curative effect of atomizing inhalation of Amikacin in the treatment of severe community-acquired pneumonia in the elderly

doi:10.3969/j.issn.1006-7795.2018.03.021

Abstract

Abstract: Objective The efficacy and safety of the treatment were discussed by atomizing inhalation of Amikacin in the treatment of elderly patients with severe community-acquired pneumonia (SCAP).Methods From January 2015 to December 2016, 106 cases of elderly patients with SCAP admitted to the department of emergency intensive care unit (EICU) in Luoyang Central Hospital affiliated to Zhengzhou University were randomly divided into the atomization group and the control group of 53 cases.There was no statistically significant difference between the two groups of age, gender, underlying disease, etiology and sensitivity to Amikacin (P>0.05).Control group was treated with conventional treatment, and atomization group was inhaled on the basis of conventional treatment.On two groups of mechanical ventilation time and ICU days, hospitalization days, antibiotic use time, Clinical Pulmonary Infection Score (CPIS) and acute Physical and Chronic Health Evaluation Ⅱ (APACHE Ⅱ), bacterial clearance rate and fatality rate, total effective rate of treatment, and 28 days adverse reactions were analyzed.Results Mechanical ventilation time, ICU days, hospitalization days and antibiotic use time of Atomization group were (7.98±2.36) d, (9.81±1.90) d, (12.68±1.65) d, (11.21±1.40) d respectively.Control group was (9.62±2.70) d, (12.34±2.72) d, (14.94±2.73) d, (13.77±2.25) d. The data of the atomization group was shorter than that of control group. The difference was statistically significant(P<0.05). The 7th day CPIS score and APACHE Ⅱ score of atomization group were significantly lower than that of control group and the admission, the difference was statistically significant(P<0.05). The total effective rate and bacterial clearance in the atomization group was 76% and 81.13%, respectively, which was higher than 56.52% and 62.26% of the control group, and the difference was statistically significant(P<0.05). The mortality rate of 28 d in atomization group was slightly lower than that in control group, and the incidence of adverse reactions was low. There was no statistically significant difference between the two groups' 28 d mortality and the incidence of adverse reactions(P>0.05).Conclusion It is safe and effective of aerosolized Amikacin in the treatment of SCAP in the elderly and worth popularizing.

Key words: inhalation, Amikacin, severe community-acquired pneumonia,elderly

CLC Number:

R459.7

Fu Liming, Zhu Ping. Observation of curative effect of atomizing inhalation of Amikacin in the treatment of severe community-acquired pneumonia in the elderly[J]. Journal of Capital Medical University, 2018, 39(3): 428-432.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2018.03.021

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2018/V39/I3/428

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