Abstract: Objective To explore the clinical characters of acute isolated traumatic brain injury-associated coagulopathy in middle aged and older populations. Methods A retrospective study was performed at Xuanwu Hospital of Capital Medical University and Shengjing Hospital of China Medical University from July 2014 to June 2016. Totally 144 cases of acute isolated traumatic brain injury were included and divided into two groups including middle aged and older patients group and non-age group with the ratio of 1:2. The chi-square analysis was used to investigate the prevalence, index and difference of coagulopathy in both groups. Results The prevalence of coagulopathy was higher in middle aged and older patients group than that of non-age group according to the chi-square analysis (P<0.05, χ²=4.11). Further, platelet count (PLT), but not international normalized ratio (INR), fibrinogen (Fg), prothrombin time (PT) and activated partial thromboplastin time (APTT),was significantly different between two groups and higher in middle aged and older patients group(P<0.05,χ²=4.68). Conclusion The higher prevalence of acute isolated traumatic brain injury-associated coagulopathy occurs in middle aged and older patients and PLT exists more likely in those populations. These findings will provide the guidance of the treatment of traumatic brain injury in middle aged and older patients in the clinical.

Key words: middle aged and older populations, acute isolated traumatic brain injury, traumatic coagulopathy, coaglution indices