Characteristic and correlationship of behavioral and psychological symptoms in patients with mild and moderate Alzheimer's disease

doi:10.3969/j.issn.1006-7795.2021.03.003

Journal of Capital Medical University ›› 2021, Vol. 42 ›› Issue (3): 354-359.doi: 10.3969/j.issn.1006-7795.2021.03.003

• Basic and Clinical Research in Neurology Field • Previous Articles Next Articles

Characteristic and correlationship of behavioral and psychological symptoms in patients with mild and moderate Alzheimer's disease

Zhan Minmin^1,2, Ma Huixuan^1,2, Kang Xuechun^1,4, Lu Xinliang^1,4, Gong Shuting^1,4, Zou Qi^1,5, Lv Jihui³, Zhou Aihong^1,2, Jia Jianping^1,2, Wei Cuibai^1,2*

1. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053,China;
2. Innovation Center for Neurological Disorders, Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China;
3. Center for Cognitive Disorders, Beijing Geriatric Hospital, Beijing 100095, China;
4. School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China;
5. Cooperation of Chinese and Western Medicine Institute, Changchun University of Traditional Chinese Medicine, Changchun 130117, China

Received:2021-03-17 Online:2021-06-21 Published:2021-06-16
Contact: *E-mail:chuibainews@126.com
Supported by:
National Key R&D Program(2016YFC1306305),National Key R&D Program of China(2017YFC1310103), Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (ZYLX201837).

Abstract

Abstract: Objective To investigate the characteristics and correlation between mental and behavioral symptoms in patients with mild and moderate Alzheimer's disease (AD). Methods According to the score of Clinical Dementia Rating Scale (CDR), 38 AD patients were divided into mild AD (n=23) and moderate AD (n=15) groups. Their mental and behavioral symptoms were assessed with Neuropsychiatric Inventory Scale (NPI). SPSS statistics 22.0 was used to analyze the characteristics and differences of NPI and its subitems between mild and moderate AD patients. The correlation rules for mental and behavioral symptoms in mild and moderate AD groups were analyzed using R software. Results Among all AD patients, the proportion of any mental and behavioral symptoms was 81.58%. The proportion was 78.26% in mild AD group, and 86.67% in moderate AD group. There was no statistical difference between the groups. In the comparison of the incidence of each subitem, there was only significant difference in the incidence of apathy between the groups (60.00% vs 26.09%, P=0.049). Comparing the severity of mental and behavioral symptoms, the NPI total score in moderate AD group was higher than that in mild AD group (10.60±8.92 vs 4.87±4.97, P=0.015). Further compaction demonstrated that the scores of apathy and aberrant motor behavior in moderate AD patients were higher than those in mild AD patients (apathy: 2.78±2.32 vs 1.04±2.18, P=0.025; aberrant motor behavior: 1.80±2.39 vs 0.30±1.26, P=0.016). Association rule analysis showed that there was a strong correlation between depression, hallucinations, delusions and apathy in mild AD patients (lift>3), and a strong correlation between night-time behavior, appetite, irritability and apathy in patients with moderate AD (lift>3). Conclusion There were differences in the incidence, severity and correlation of mental and behavioral symptoms between the mild AD patients and moderate AD patients.

Key words: Alzheimer's disease, behavioral and psychological symptoms, clinical features

CLC Number:

R749.16

Zhan Minmin, Ma Huixuan, Kang Xuechun, Lu Xinliang, Gong Shuting, Zou Qi, Lv Jihui, Zhou Aihong, Jia Jianping, Wei Cuibai. Characteristic and correlationship of behavioral and psychological symptoms in patients with mild and moderate Alzheimer's disease[J]. Journal of Capital Medical University, 2021, 42(3): 354-359.

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Characteristic and correlationship of behavioral and psychological symptoms in patients with mild and moderate Alzheimer's disease

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