Progresses on the effect of estrogen on innate immune cells

doi:10.3969/j.issn.1006-7795.2023.02.025

Abstract

Abstract: The immune system has gender dimorphism. Females mount stronger innate immunity and adaptive immune response than males, and female sensitivity to multiple pathogenic infections and malignant tumors is lower. Meanwhile, women are more likely to develop autoimmune diseases. One of the important factors responsible for these sex differences, estrogen, exerts a wide range of biological effects in the human body. Currently, estrogen has been reported to regulate the differentiation, maturation, longevity, and effector function of innate immune cells, including neutrophils, monocytes and macrophages, natural killer cells, and dendritic cells. This review discusses in detail how estrogen regulates the normal physiological function of immune cells and its different roles in various disease states.

Key words: estrogen, estrogen receptors, innate immune cells

CLC Number:

R392.9

Li Ziyi, Wang Xi, Liang Pu. Progresses on the effect of estrogen on innate immune cells[J]. Journal of Capital Medical University, 2023, 44(2): 351-357.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2023.02.025

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2023/V44/I2/351

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