Influence of general anesthesia combined with epidural block on liver and kidney function after liver resection

doi:10.3969/j.issn.1006-7795.2017.03.005

Abstract

Abstract: Objective To explore the influence of different anesthetic drugs for general anesthesia combined with epidural block on liver and kidney function after liver resection. Methods Totally 123 patients with liver resection were selected from Beijing Ditan Hospital who underwent general anesthesia combined with epidural block from October 2014 to October 2015. Patients were divided into three groups by simple random sampling. Forty-one patients were treated with sevoflurane as group A. Another 41 patients were treated with isoflurane as group B. Additional 41 patients were treated with propofol as group C. The result of liver and kidney function tests at different time points were compared among the three groups. Results After operation,alanine aminotransferase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), total bilirubin (TBiL), γ-glutamyltranspeptidase (γ-GT), urea nitrogen (BUN), serum creatinine (SCr), α1-microglobulin (α1-MG), albumin (ALB), lactic dehydrogenase (LDH) increased firstly and then decreased in each of the three groups(P<0.05). ALT, AST, ALP, TBiL, γ-GT, BUN, SCr, α1-MG, ALB, LDH at postoperative day 1, day 3 in group B were higher than those of group A(P<0.05). ALT, AST, ALP, TBiL, γ-GT, BUN, SCr, α1-MG, ALB, LDH at postoperative day 1, day 3 in group C were higher than those of group A and B(P<0.05). Conclusion In liver resection, sevoflurane, or isoflurane, propofol can be used for general anesthesia combined with epidural block. Sevoflurane showed less effect on liver and kidney function, and had more safety profile.

Key words: sevoflurane, isoflurane, propofol, liver resection, liver and kidney function

CLC Number:

R614

Cai Xiaofei, Niu Shaoning, Ding Qiao, Cheng Hao. Influence of general anesthesia combined with epidural block on liver and kidney function after liver resection[J]. Journal of Capital Medical University, 2017, 38(3): 352-356.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2017.03.005

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2017/V38/I3/352

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