关键词: 原发性高血压, 血压变异性, 肾脏损害, 估算肾小球率过滤

Abstract: Objective To explore possible correlation between blood pressure variability and impaired renal function in hypertensive patients. Methods Twenty-four-hour ambulatory blood pressure monitoring(ABPM) was performed in 106 hypertensive patients. The estimated glomerular filtration rate(eGFR) was assessed using the abbreviated equation of the modification diet for renal disease(MDRD) study. Patients were divided into two groups: those with an eGFR less than 90 mL/min per 1.73 m²(group A) and those with an eGFR 90 mL/min per 1.73 m² or more( group B). Results Patients with low eGFR levels had higher 24 h-diastolic blood pressure(24 h-DBP) and higher 24 h-systolic blood pressure-standard deviation(24 h SBP-SD) in comparison to those with normal eGFR levels. The multivariable Logistic regression analysis showed that the negative relation between 24 h-DBP, 24 h SBP-SD and eGFR persisted(OR=0.913, P=0.019; OR=0.803, P=0.049, respectively) even after adjustment for age, male sex. Conclusion Besides blood pressure level, BPV level is also related to impaired renal function.

Key words: essential hypertension, blood pressure variability, renal injury, estimated glomerular filtration rate(eGFR)