首都医科大学学报 ›› 2011, Vol. 32 ›› Issue (5): 626-628.doi: 10.3969/j.issn.1006-7795.2011.05.008

• 心血管疾病及其危险因素 • 上一篇    下一篇

原发性高血压患者血压变异性与肾功能损害的相关研究

侯海霞, 华琦, 陈慧敏, 刘荣坤, 杨峥   

  1. 首都医科大学宣武医院心脏科,北京 100053
  • 收稿日期:2011-07-21 修回日期:1900-01-01 出版日期:2011-10-21 发布日期:2011-10-21
  • 通讯作者: 华 琦

Correlation between blood pressure variability and renal dysfunction in patients with primary hypertension

HOU Hai-xia, HUA Qi, CHEN Hui-min, LIU Rong-kun, YANG Zheng   

  1. Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
  • Received:2011-07-21 Revised:1900-01-01 Online:2011-10-21 Published:2011-10-21

PDF

354

被引次数

46

摘要： 目的 探讨原发性高血压患者血压变异性与肾功能损害之间的关系。方法 对106例原发性高血压患者行24 h动态血压监测,采用简化肾脏病膳食改良试验(modification diet for renal disease,MDRD)方程估算肾小球滤过率(estimated glomerular filtration rate,eGFR),并根据eGFR值将患者分为2组:每1.73 m2 eGFR<90 mL/min(A组)与每1.73m2 eGFR≥90 mL/min(B组)。结果 A组患者的24 h平均舒张压(24 h-diastolic blood pressure,24 h-DBP)、24 h收缩压变异性(24 h-systolic blood pressure-standard deviation, 24 h SBP-SD)均显著高于B组,将其带入回归方程并校正年龄、性别因素后,发现24 h-DBP(OR=0.913,P=0.019)、24 h SBP-SD(OR=0.803, P=0.049)仍与eGFR独立相关。结论 除血压水平外,血压变异性与高血压患者的肾脏损伤程度密切相关。

关键词: 原发性高血压, 血压变异性, 肾脏损害, 估算肾小球率过滤

Abstract: Objective To explore possible correlation between blood pressure variability and impaired renal function in hypertensive patients. Methods Twenty-four-hour ambulatory blood pressure monitoring(ABPM) was performed in 106 hypertensive patients. The estimated glomerular filtration rate(eGFR) was assessed using the abbreviated equation of the modification diet for renal disease(MDRD) study. Patients were divided into two groups: those with an eGFR less than 90 mL/min per 1.73 m2(group A) and those with an eGFR 90 mL/min per 1.73 m2 or more( group B). Results Patients with low eGFR levels had higher 24 h-diastolic blood pressure(24 h-DBP) and higher 24 h-systolic blood pressure-standard deviation(24 h SBP-SD) in comparison to those with normal eGFR levels. The multivariable Logistic regression analysis showed that the negative relation between 24 h-DBP, 24 h SBP-SD and eGFR persisted(OR=0.913, P=0.019; OR=0.803, P=0.049, respectively) even after adjustment for age, male sex. Conclusion Besides blood pressure level, BPV level is also related to impaired renal function.

Key words: essential hypertension, blood pressure variability, renal injury, estimated glomerular filtration rate(eGFR)

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